ArticleNature immunology2017
The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
128 citing papers in PubMed, 2 syntheses or guidelines pooled it, 265 citations in OpenAlex.
- Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies.Particle and fibre toxicology · 2020Pooled it
- [Air pollution and atopic eczema : Systematic review of findings from environmental epidemiological studies].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2019Pooled it
- Benzo[a]pyrene vs. Tapinarof: unraveling ligand-specific AHR transcriptional responses in immortalized keratinocytes.Archives of toxicology · 2026Article
- Comparative 28-day mouse study of topically applied aryl hydrocarbon receptor ligands: microbiota-derived indoles, therapeutic tapinarof, pollutants 2,3,7,8-tetrachlorodibenzo-p-dioxin and diesel exhaust particles.Chemico-biological interactions · 2026Article
- Atopic dermatitis.Nature reviews. Disease primers · 2026Review
- Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Review
- Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis.The Journal of dermatology · 2026Review
- [Effects of particulate matter pollution on human skin].Dermatologie (Heidelberg, Germany) · 2026Review
- The Intervention Effect of Externally Applying or Orally AdministeringMicroorganisms · 2026Article
- Integrative transcriptomic analysis identifies CCL22-associated immune signatures in air pollution-related atopic dermatitis.Frontiers in public health · 2026Article
- Global research trends on the aryl hydrocarbon receptor in atopic dermatitis: a bibliometric and visualized analysis.Frontiers in medicine · 2026Article
- Chromatin Accessibility Profiling of Keratinocytes from Clinically Healed Psoriatic Skin Reveals Epigenetic Alterations.JID innovations : skin science from molecules to population health · 2026Article
- The Impact of Early-Life, Long-Term Exposure to Ambient Particulate Matter on Atopic Dermatitis Remission and Sensitization in Infants.Journal of Korean medical science · 2025Article
- Unraveling the Pathogenesis of Asian Atopic Dermatitis: Key Characteristics and Insights.Annals of dermatology · 2025Review
- Association between dietary preferences and asthma among first-grade primary school children.Pediatric investigation · 2025Article
- Atopic Dermatitis and Climate: Environmental Stressors and Care Strategies.Dermatology and therapy · 2025Review
- Gene-environment interaction analysis in atopic eczema: evidence from large population datasets and modellingmedRxiv : the preprint server for health sciences · 2025Article
- Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.Allergy · 2025Article
- Vitamin D and skin disorders: bridging molecular insights to clinical innovations.Molecular medicine (Cambridge, Mass.) · 2025Review
68 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor). Through the use of AhR-CA mice, whose keratinocytes express constitutively active AhR and that develop atopic-dermatitis-like phenotypes, we identified Artn as a keratinocyte-specific AhR target gene whose product (the neurotrophic factor artemin) was responsible for epidermal hyper-innervation that led to hypersensitivity to pruritus. The activation of AhR via air pollutants induced expression of artemin, alloknesis, epidermal hyper-innervation and inflammation. AhR activation and ARTN expression were positively correlated in the epidermis of patients with atopic dermatitis. Thus, AhR in keratinocytes senses environmental stimuli and elicits an atopic-dermatitis pathology. We propose a mechanism of air-pollution-induced atopic dermatitis via activation of AhR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.