Evidence map›Paper›PMID 27869797›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2017

The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice.

Laura M Hansen, Divya Gupta, Giji Joseph, Daiana Weiss, W Robert Taylor

Open access · bronzeAbstract read
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

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  10. A Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Article
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  14. AGE-RAGE Axis in the Pathophysiology of Chronic Lower Limb Ischemia and a Novel Strategy for Its Treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laura M HansenDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.
Divya GuptaDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.
Giji JosephDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.
Daiana WeissDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.
W Robert TaylorDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory University · USGeorgia Institute of Technology · US

Funding

T cell triggering events and hypertensionP01HL095070 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 2009 to 2019
$20.5M
Research Trainng in Academic CardiologyT32HL007745 · NHLBI · EMORY UNIVERSITY · PI TAYLOR, WILLIAM ROBERT · 1994 to 2023
$10.6M
The Role of Hydrogen Peroxide in RAGE Expression in Collateral Vessel FormationF32HL124974 · NHLBI · EMORY UNIVERSITY · PI HANSEN, LAURA MARIE · 2015 to 2017
$173k
NHLBI NIH HHS F32 HL124974NHLBI NIH HHS P01 HL095070NHLBI NIH HHS T32 HL007745
6 · The paper itself

Abstract

Diabetics often have poor perfusion in their limbs as a result of peripheral artery disease and an impaired ability to generate collateral vessels. The receptor for advanced glycation end products (RAGE) is one protein that is thought to play a detrimental role in collateral development in diabetics due to increased levels of advanced glycation end products (AGE), one of its ligands, in diabetes. Thus, the aim of this study was to investigate the role of RAGE in both diabetic and non-diabetic settings in a model of collateral formation in mice. Streptozotocin was used to induce diabetes in both wild type and RAGE knockout mice. Increased levels of the AGE, N

Indexed as

Collateral CirculationAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalDiabetic AngiopathiesGlycation End Products, AdvancedHindlimbHMGB1 ProteinImmunoblottingImmunohistochemistryIschemiaLipidsLysineMaleMice, Inbred C57BLMice, KnockoutBlood GlucoseGlycation End Products, AdvancedHMGB1 ProteinLipidsLysineN(6)-carboxymethyllysineReceptor for Advanced Glycation End Products

Identifiers

PMID27869797
PMCPMC5214531
OpenAlexW2552761363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.