ArticleNature microbiology2016
Lyme disease spirochaete Borrelia burgdorferi does not require thiamin.
Open access · greenAbstract read
In one paragraph
Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Investigating Coenzyme Function of Thiamine Triphosphate Using Its Novel Hydrolysis-Resistant Analog and Transketolase.Biomolecules · 2026Article
- Article
- Lactate dehydrogenase is the Achilles' heel of Lyme disease bacteriumbioRxiv : the preprint server for biology · 2025Article
- Why pyridoxal phosphate could be a functional predecessor of thiamine pyrophosphate and speculations on a primordial metabolism.RSC chemical biology · 2024Review
- Metabolic modeling predicts unique drug targets inmSystems · 2023Article
- Lactate Dehydrogenase Inhibitors SuppressPathogens (Basel, Switzerland) · 2023Article
- Dietary factors potentially impacting thiaminase I-mediated thiamine deficiency.Scientific reports · 2023Article
- Genetic basis of thiaminase I activity in a vertebrate, zebrafish Danio rerio.Scientific reports · 2023Article
- On the Evolutionary History of the Twenty Encoded Amino Acids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- The Involvement of Thiamine Uptake in the Virulence ofPathogens (Basel, Switzerland) · 2022Article
- Pyridoxal and α-Ketoglutarate Independently Improve Function of Saccharomyces cerevisiae Thi5 in the Metabolic Network of Salmonella enterica.Journal of bacteriology · 2022Article
- The environment, the tick, and the pathogen - It is an ensemble.Frontiers in cellular and infection microbiology · 2022Review
- The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar.Nature microbiology · 2021Article
- Interactions between Borrelia burgdorferi and ticks.Nature reviews. Microbiology · 2020Review
- GTP cyclohydrolase I activity from Rickettsia monacensis strain Humboldt, a rickettsial endosymbiont of Ixodes pacificus.Ticks and tick-borne diseases · 2020Article
- Ixodes scapularis does not harbor a stable midgut microbiome.The ISME journal · 2018Article
- Thiaminase I Provides a Growth Advantage by Salvaging Precursors from Environmental Thiamine and Its Analogs in Burkholderia thailandensis.Applied and environmental microbiology · 2018Article
- The folA gene from the Rickettsia endosymbiont of Ixodes pacificus encodes a functional dihydrofolate reductase enzyme.Ticks and tick-borne diseases · 2018Article
- Thiamine and selected thiamine antivitamins - biological activity and methods of synthesis.Bioscience reports · 2018Review
- Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network ofMicrobial cell (Graz, Austria) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Kai ZhangDepartment of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA.
Jiang BianDepartment of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA.
Yijie DengDepartment of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA.
Alexis SmithDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA.
Roy E NunezDepartment of Biological Sciences, The City University of New York, New York, New York 10021, USA.
Michael B LiDepartment of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA.
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA.
Ai-Ming YuDepartment of Biochemistry &Molecular Medicine, UC Davis School of Medicine, Sacramento, California 95817, USA.
Weigang QiuDepartment of Biological Sciences, The City University of New York, New York, New York 10021, USA.ORCID http://orcid.org/0000-0003-4585-1872
Steven E EalickDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
Chunhao LiDepartment of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA.
University at Buffalo, State University of New York · USCity University of New York · USUniversity of Maryland, College Park · USCornell University · USUniversity of California Davis Medical Center · US
Funding
RISE Program Hunter College Option IIIR25GM060665 · NIGMS · HUNTER COLLEGE · PI ORTIZ, BENJAMIN D.,, SERRANO, PETER A · 2000 to 2022
$22.8MUndergraduate Biomedical Research Training at HunterT34GM007823 · NIGMS · HUNTER COLLEGE · PI FORD, JENNIFER S · 1985 to 2020
$8.2MUnderstanding Unique Aspects of Motility and Chemotaxis in Borrelia burgdorferiR01AI078958 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI Chunhao Chris Li · 2008 to 2026
$5.7MExploring New Virulence Factors of the Oral Spirochete Treponema denticolaR01DE023080 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI Chunhao Chris Li · 2013 to 2026
$5.2MBORRELIA GENE PRODUCTS CRITICAL FOR NATURAL INFECTION CYCLER01AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2009 to 2024
$5.2MStructural Studies of Enzymes of Thiamin BiosynthesisR01DK067081 · NIDDK · CORNELL UNIVERSITY ITHACA · PI EALICK, STEVEN E · 2005 to 2017
$4.2MGenome Variability and Population Processes of Lyme Disease PathogensSC1AI107955 · NIAID · HUNTER COLLEGE · PI QIU, WEIGANG · 2013 to 2016
$1.1MGenomic & Host Drivers of Borrelia DiversificationR21AI139782 · NIAID · HUNTER COLLEGE · PI QIU, WEIGANG · 2018 to 2019
$429kBorella Gene Products Critical For Natural Infection CycleR56AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2013 to 2013
$357kNIAID NIH HHS R01 AI078958NIAID NIH HHS R01 AI080615NIAID NIH HHS R21 AI139782NIAID NIH HHS R56 AI080615NIAID NIH HHS SC1 AI107955NIDCR NIH HHS R01 DE023080NIDDK NIH HHS R01 DK067081NIGMS NIH HHS R25 GM060665NIGMS NIH HHS T34 GM007823
Abstract
Thiamin pyrophosphate (ThDP), the active form of thiamin (vitamin B
Indexed as
AnimalsBorrelia burgdorferiChromatography, High Pressure LiquidIxodesMicrobial ViabilityThiamineThiamine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.