ReviewMolecules (Basel, Switzerland)2016
Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine.
Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Ribosome-Inactivating Proteins fromBiomedicines · 2026Article
- Antiviral Potential ofBiomedicines · 2026Review
- Profiling and cheminformatics bioprospection of curcurbitacin I and momordin Ic fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
- Ricin Toxicity to Intestinal Cells Leads to Multiple Cell Death Pathways Mediated by Oxidative Stress.Toxins · 2025Article
- Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.Nutrients · 2024Review
- Review
- Article
- Medical Countermeasures against Ricin Intoxication.Toxins · 2023Review
- Antibacterial Activity fromPharmaceutics · 2022Article
- Article
- Sequence, Structure, and Binding Site Analysis of Kirkiin in Comparison with Ricin and Other Type 2 RIPs.Toxins · 2021Article
- Influence of Plant Origins and Seasonal Variations on Nutritive Values, Phenolics and Antioxidant Activities ofFoods (Basel, Switzerland) · 2021Article
- Article
- Ribosome-Inactivating Proteins ofToxins · 2021Article
- Anti-demodectic effects of okra eyelid patch inExperimental and therapeutic medicine · 2021Article
- In Vitro Phytotherapeutic Properties of Aqueous ExtractedMolecules (Basel, Switzerland) · 2021Article
- Article
- Editorial: Toxic Plant Proteins as Experimental Drugs for Human Pathologies.Frontiers in pharmacology · 2021Article
- Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature.International journal of nanomedicine · 2021Review
- Article
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Authors and funding
5 authors.
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Abstract
Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their toxicity. This review analyses the position occupied in traditional medicine by plants from which RIPs have been isolated. The overview starts from the antique age of the Mediterranean area with ancient Egypt, followed by the Greek and Roman classic period. Then, the ancient oriental civilizations of China and India are evaluated. More recently, Unani medicine and European folk medicine are examined. Finally, the African and American folk medicines are taken into consideration. In conclusion, a list of RIP-expressing plants, which have been used in folk medicine, is provided with the geographical distribution and the prescriptions that are recommended by traditional healers. Some final considerations are provided on the present utilization of such herbal treatments, both in developing and developed countries, often in the absence of scientific validation. The most promising prospect for the medicinal use of RIP-expressing plants is the conjugation of purified RIPs to antibodies that recognise tumour antigens for cancer therapy.
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