ArticleInternational journal of environmental research and public health2016
Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat.
Article in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Systemic Effects of Repeated Intraperitoneal Application of Graphene Oxide and Polyethylene Glycol-Functionalized Graphene Oxide Nanoparticles in Long Evans Male Rats.International journal of molecular sciences · 2026Article
- Assessment of neurobehavioral and histopathological impacts of graphene quantum Dots in NMRI mice.Scientific reports · 2025Article
- Research on the impact of graphene oxide in feed on growth and health parameters in calves.Frontiers in toxicology · 2025Article
- Graphene Oxide Significantly Modifies Cardiac Parameters and Coronary Endothelial Reactivity in Healthy and Hypertensive Rat HeartsACS omega · 2024Article
- Maize auxin response factor ZmARF1 confers multiple abiotic stresses resistances in transgenic Arabidopsis.Plant molecular biology · 2024Article
- Molecular mechanism of nanomaterials induced liver injury: A review.World journal of hepatology · 2024Review
- Short term biodistribution and in vivo toxicity assessment of intravenously injected pristine graphene oxide nanoflakes in SD rats.Toxicology research · 2024Article
- Review
- Oriented Graphene Oxide Scaffold Promotes Nerve Regeneration in vitro and in vivo.International journal of nanomedicine · 2024Article
- Recent advances in nanoantibiotics against multidrug-resistant bacteria.Nanoscale advances · 2023Review
- Biological Responses in the Blood and Organs of Rats to Intraperitoneal Inoculation of Graphene and Graphene Oxide.Materials (Basel, Switzerland) · 2022Article
- The In Vivo Toxicity Assessments of Water-Dispersed Fluorescent Silicon Nanoparticles inInternational journal of environmental research and public health · 2022Article
- Hepatotoxicity of graphene oxide in Wistar rats.Environmental science and pollution research international · 2021Article
- Synthesis and Toxicity of Graphene Oxide Nanoparticles: A Literature Review ofBioMed research international · 2021Review
- Acute and Subchronic Oral Toxicity of Oil Palm Puree in Sprague-Dawley Rats.International journal of environmental research and public health · 2020Article
- Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering.International journal of nanomedicine · 2019Review
- Short-term inhalation study of graphene oxide nanoplates.Nanotoxicology · 2018Article
- Improved Anticancer Effect of Magnetite Nanocomposite Formulation of GALLIC Acid (Fe₃O₄-PEG-GA) Against Lung, Breast and Colon Cancer Cells.Nanomaterials (Basel, Switzerland) · 2018Article
- In vivo toxicological evaluation of graphene oxide nanoplatelets for clinical application.International journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene oxide (GO) is an oxidized derivative of graphene used in biotechnology and medicine. The safety of GO is uncertain, so we evaluated its toxicity in male rats. Rat tail veins were injected with 2.5, 5, or 10 mg/kg GO for seven days and behavioral patterns, pathology, and tissue morphology were assessed. Data show that behaviors were not altered according to an open field test and a functional observational battery test, but histopathological analysis indicated that GO caused inflammation of the lung, liver, and spleen. GO also reduced cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). No other organs were modified. Thus, high concentrations of GO are toxic for the lung, liver, and spleen, but the mechanism by which this occurs requires more study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.