ArticleEmerging infectious diseases2016
Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015.
Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Ebola virus and Sudan virus infection in humans: a comparison to inform vaccine research and development.Emerging microbes & infections · 2026Review
- Association between serum calcium and in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a retrospective cohort study.Virology journal · 2026Article
- Development of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo.EClinicalMedicine · 2022Article
- Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Hyponatremia, Inflammation at Admission, and Mortality in Hospitalized COVID-19 Patients: A Prospective Cohort Study.Frontiers in medicine · 2021Article
- Hyponatremia in Infectious Diseases-A Literature Review.International journal of environmental research and public health · 2020Review
- Article
- Nutritional Care for Patients with Ebola Virus Disease.Emerging infectious diseases · 2020Review
- Pulmonary Involvement during the Ebola Virus Disease.Viruses · 2019Review
- Enhanced case management can be delivered for patients with EVD in Africa: Experience from a UK military Ebola treatment centre in Sierra Leone.The Journal of infection · 2018Article
- Insights from clinical research completed during the west Africa Ebola virus disease epidemic.The Lancet. Infectious diseases · 2017Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia. Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently associated with increased risk for death. A prognostic model using all 5 factors was highly discriminatory (area under the receiver operating curve 0.95; 95% CI 0.90-0.99) and enabled the definition of risk criteria to guide targeted care. Most patients had a very low (<5%) or very high (>80%) risk for death.
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