ReviewEpigenomics2016
The epigenetic impacts of social stress: how does social adversity become biologically embedded?
Review in Epigenomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Optimizing Outcomes: A Systematic Review of Psychosocial Risk Factors Affecting Perinatal Black/African-American Women with Substance Use Disorder in the United States.Maternal and child health journal · 2022Pooled it
- How are social determinants of health integrated into epigenetic research? A systematic review.Social science & medicine (1982) · 2021Pooled it
- An epigenome-wide association study meta-analysis of educational attainment.Molecular psychiatry · 2017Pooled it
- Genetic insights into socioeconomic inequalities and adiposity-related interventions for reducing accelerated biological aging.International journal of obesity (2005) · 2026Observational
- Geographic Measures of Early Life-Course Social Exposome in the Evaluation of Structural Neuroanatomy: A Scoping Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Psychosocial stressors, accelerated biological aging, and multiple morbidities: Evidence from an age-diverse sample.PloS one · 2026Article
- Stress-induced epigenome changes as a risk factor in the onset of mental disorders.Frontiers in psychiatry · 2026Review
- Neighborhood disadvantage and elevated CD14 gene expression among middle-aged adults: Findings from the Midlife in the United States study.Psychoneuroendocrinology · 2025Article
- Cell-Derived Epigenomic Markers of Chronic Stress Distinguish Breast Cancer Phenotypes.The Yale journal of biology and medicine · 2025Article
- Mom genes and dad genes: genomic imprinting in the regulation of social behaviors.Epigenomics · 2025Review
- Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.PLoS genetics · 2025Article
- Is virtue its own reward? Moral identity, empathy, and volunteering during adolescence as predictors of subsequent epigenetic aging.Applied psychology. Health and well-being · 2025Article
- Adolescent empathy and epigenetic aging in adulthood: Substance use as a mediator.Developmental psychology · 2025Article
- 20-Year income volatility and cognitive function in the National Longitudinal Survey of Youth (1979) cohort: A replication and extension of CARDIA findings.Social science & medicine (1982) · 2025Article
- Repeated social stress increases posterior medial amygdala neuronal activity in stress-susceptible adult male rats.Journal of neurophysiology · 2025Article
- Prolonged physical isolation, agonistic behaviour, and human resilience in pandemic times.Frontiers in public health · 2025Article
- Review
- Immune gene regulation is associated with age and environmental adversity in a nonhuman primate.Molecular ecology · 2024Article
- DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults.Human molecular genetics · 2024Article
- Life-Course Socioeconomic Trajectories and Biological Aging: The Importance of Lifestyles and Physical Wellbeing.Nutrients · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Epigenetic mechanisms are implicated in the processes through which social stressors erode health in humans and other animals. Here I review progress in elucidating the biological pathways underlying the social gradient in health, with particular emphasis on how behavioral stresses influence epigenomic variation linked to health. The evidence that epigenetic changes are involved in embedding of social status-linked chronic stress is reviewed in the context of current knowledge about behavior within animal dominance hierarchies and the impacts of social position on behaviors that affect health. The roles of epigenetic mechanisms in responses to trauma and the evidence for their involvement in intergenerational transmission of the biological impacts of traumatic stress are also considered. Taken together, the emerging insights have important implications for development of strategies to improve societal health and well-being.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.