Evidence map›Paper›PMID 27869292›Full record

ArticleBiotechnology and bioengineering2017

Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.

Si Nga Sou, Philip M Jedrzejewski, Ken Lee, Christopher Sellick, Karen M Polizzi, Cleo Kontoravdi

Open access · hybridAbstract read
In one paragraph

Article in Biotechnology and bioengineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A consensus-based and readable extension ofBeilstein journal of organic chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Si Nga SouDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Philip M JedrzejewskiDepartment of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London SW7 2AZ, United Kingdom.
Ken LeeCell Culture and Fermentation Sciences, MedImmune, Granta Park, Cambridge, United Kingdom.
Christopher SellickCell Culture and Fermentation Sciences, MedImmune, Granta Park, Cambridge, United Kingdom.
Karen M PolizziDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Cleo KontoravdiDepartment of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-0213-4830
Imperial College London · GBGranta Design (United Kingdom) · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (q

Indexed as

Models, ImmunologicalAnimalsAntibodies, MonoclonalCHO CellsComputer SimulationCricetulusGlycosylationGlycosyltransferasesHeatingImmunoglobulin Fc FragmentsPolysaccharidesTemperatureAntibodies, MonoclonalGlycosyltransferasesImmunoglobulin Fc FragmentsPolysaccharidesCHO cellsflux balance analysisgalactosylationmathematical modelingmild hypothermiamonoclonal antibodyN-linked glycosylation

Identifiers

PMID27869292
PMCPMC5485029
OpenAlexW2557078512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.