ArticleScientific reports2016
Structural and immunomodulatory differences among lactobacilli exopolysaccharides isolated from intestines of mice with experimentally induced inflammatory bowel disease.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- What happens to Bifidobacterium adolescentis and Bifidobacterium longum ssp. longum in an experimental environment with eukaryotic cells?BMC microbiology · 2024Article
- Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms.Microbial cell factories · 2023Article
- Gut health benefit and application of postbiotics in animal production.Journal of animal science and biotechnology · 2022Review
- Molecular and Cellular Mechanisms Influenced by Postbiotics.International journal of molecular sciences · 2021Review
- Selenium-Containing Exopolysaccharides Isolated from the Culture Medium ofInternational journal of molecular sciences · 2021Article
- Cell-Free Lactobacillus casei 21L10 Modulates Nitric Oxide Release and Cell Proliferation/Cell Death in Lipopolysaccharide-Challenged HT-29 Cells.Inflammation · 2021Article
- Effect of exopolysaccharides from cariogenic bacteria on human gingival fibroblasts.International journal of medical sciences · 2021Article
- Exopolysaccharides from probiotic bacteria and their health potential.International journal of biological macromolecules · 2020Review
- The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health.FEMS microbiology reviews · 2020Review
- Exopolysaccharide from Lactobacillus rhamnosus KL37 Inhibits T Cell-dependent Immune Response in Mice.Archivum immunologiae et therapiae experimentalis · 2020Article
- Identification of Genes Required for Glucan Exopolysaccharide Production in Lactobacillus johnsonii Suggests a Novel Biosynthesis Mechanism.Applied and environmental microbiology · 2020Article
- Molecules Produced by Probiotics and Intestinal Microorganisms with Immunomodulatory Activity.Nutrients · 2020Review
- Paraprobiotics and Postbiotics of ProbioticFrontiers in nutrition · 2020Review
- Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis.Glycoconjugate journal · 2019Article
- Article
- Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective.Frontiers in microbiology · 2018Review
- Interactions of Surface Exopolysaccharides FromFrontiers in microbiology · 2018Review
- Fecal Microbiota Transplantation, CommensalFrontiers in microbiology · 2017Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characteristic changes in the microbiota biostructure and a decreased tolerance to intestinal bacteria have been associated with inflammatory bowel disease (IBD). However, few studies have examined the constituents of the intestinal microbiota, including the surface molecules of the bacteria, in healthy and IBD subsets. Here, we compare the chemical structures and immunomodulatory properties of the exopolysaccharides (EPS) of lactobacilli isolated from mice with induced IBD (IBD "+") versus those of healthy mice (IBD "-"). Classical structural analyses were performed using nuclear magnetic resonance spectroscopy and mass spectrometry. Immunomodulatory properties were assessed by stimulation of dendritic cells derived from mouse bone marrow or human peripheral mononuclear blood cells. Our results revealed that EPS produced by IBD "+" species are structurally different from those isolated from IBD "-". Moreover, the structurally different EPS generate different immune responses by dendritic cells. We speculate that resident strains could, upon gut inflammation, switch to producing EPS with specific motifs that are absent from lactobacilli IBD "-", and/or that bacteria with a particular EPS structure might inhabit the inflamed intestinal mucosa. This study may shed light on the role of EPS in IBD and help the development of a specific probiotic therapy for this disease.
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