ArticleScientific reports2016
Interleukins 17 and 23 in patients with gastric neoplasms.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetically Predicted Circulating Levels of Cytokines and the Risk of Cancer.Frontiers in immunology · 2022Pooled it
- Genetic polymorphisms of IL-17A rs2275913, rs3748067 and IL-17F rs763780 in gastric cancer risk: evidence from 8124 cases and 9873 controls.Molecular biology reports · 2018Pooled it
- IL-17A in gastric carcinogenesis: good or bad?Frontiers in immunology · 2024Review
- Endoscopic findings in the upper gastrointestinal tract in patients with Crohn's disease are common, highly specific, and associated with chronic gastritis.Scientific reports · 2023Article
- High endothelial venule is a surrogate biomarker for T-cell inflamed tumor microenvironment and prognosis in gastric cancer.Journal for immunotherapy of cancer · 2021Article
- Association between interleukin gene polymorphisms and susceptibility to gastric cancer in the Qinghai population.The Journal of international medical research · 2021Article
- The Roles of IL-17, IL-21, and IL-23 in theToxins · 2021Review
- Lipoxins and Resolvins in Patients With Pancreatic Cancer: A Preliminary Report.Frontiers in oncology · 2021Article
- TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case-control study.Scientific reports · 2020Article
- Association between human leukocyte antigen gene polymorphisms and multiple EPIYA-C repeats in gastrointestinal disorders.World journal of gastroenterology · 2020Article
- Genomic analysis and clinical implications of immune cell infiltration in gastric cancer.Bioscience reports · 2020Article
- Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis.International journal of molecular sciences · 2020Review
- Clinical significance of various growth factors in patients with different gastric neoplasms.American journal of translational research · 2020Article
- A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Notch signaling pathway regulates CD4Bioscience reports · 2019Article
- Hydroxyeicosatetraenoic acids in patients with pancreatic cancer: a preliminary report.American journal of cancer research · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently there has been heightened interest in the potential significance of interleukin (IL)-17 and IL-23 in the development/progression of human malignancies. Here, we analyzed the systemic levels of these cytokines in 75 patients with different types of gastric neoplasms (carcinoma, gastrointestinal stromal tumors, neuroendocrine neoplasms, and lymphomas) and 42 healthy volunteers. We found that patients with all types of gastric neoplasms have significantly lower IL-23 levels. However, in comparison to the levels in healthy individuals, IL-17 concentrations were lower only in patients with types of gastric neoplasms other than carcinoma. Interestingly, IL-17 levels significantly differed between patients with early and advanced gastric carcinoma. No significant associations were detected between the systemic levels of examined interleukins and TNM staging. However, peripheral levels of IL-23 were correlated with the absolute numbers of circulating populations of bone marrow-derived mesenchymal and very small embryonic/epiblast-like stem cells in patients with gastric carcinoma. ROC curve analyses demonstrated that systemic levels of IL-17 seem to meet basic criteria for consideration as a helpful diagnostic marker in the detection of gastric carcinoma. In conclusion, our study provides translational evidence confirming the clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms in humans.
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