ArticleNature communications2016
Autophagy controls centrosome number by degrading Cep63.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Sensing centrosome amplification: the interface between centriole duplication and autophagy.Nature communications · 2026Article
- Centriolar satellites regulatebioRxiv : the preprint server for biology · 2026Article
- The Kifc3 Motor Protein Controls Centrosomal Factor Cep192 in Ontogenic Coordination of Megakaryocyte Development.bioRxiv : the preprint server for biology · 2026Article
- DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability.Nature communications · 2023Article
- CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.Oncogene · 2022Article
- Centrosome function is critical during terminal erythroid differentiation.The EMBO journal · 2022Article
- Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights.Blood science (Baltimore, Md.) · 2022Review
- Microtubule organizing centers regulate spindle positioning in mouse oocytes.Developmental cell · 2022Article
- Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions.International journal of biological sciences · 2022Review
- Article
- The human sperm basal body is a complex centrosome important for embryo preimplantation development.Molecular human reproduction · 2021Article
- Generation and Fates of Supernumerary Centrioles in Dividing Cells.Molecules and cells · 2021Review
- Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1.Oncology reports · 2021Article
- Article
- Centrosome-phagy: implications for human diseases.Cell & bioscience · 2021Review
- Prognostic Immunity and Therapeutic Sensitivity Analyses Based on Differential Genomic Instability-Associated LncRNAs in Left- and Right-Sided Colon Adenocarcinoma.Frontiers in molecular biosciences · 2021Article
- Autophagy involvement in oncogenesis.Cancer science · 2020Review
- Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition.Molecular cancer research : MCR · 2020Article
- Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.PLoS genetics · 2020Article
- Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.Nature communications · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin-proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.