ArticleThe Journal of clinical investigation1989
Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 133 citations in OpenAlex.
- Enhanced Electroactive Phases of Poly(vinylidene Fluoride) Fibers for Tissue Engineering Applications.International journal of molecular sciences · 2024Article
- Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis.Molecules (Basel, Switzerland) · 2021Review
- Biochemical Changes in the Niche Following Tumor Cell Invasion.Journal of cellular biochemistry · 2017Review
- Bone: A Fertile Soil for Cancer Metastasis.Current drug targets · 2017Review
- Synergistic effect of SCF and G-CSF on stem-like properties in prostate cancer cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis.Chinese journal of cancer · 2011Review
- Cancer to bone: a fatal attraction.Nature reviews. Cancer · 2011Review
- Osteoblast-derived factors induce an expression signature that identifies prostate cancer metastasis and hormonal progression.Cancer research · 2009Article
- Osteoblasts induce prostate cancer proliferation and PSA expression through interleukin-6-mediated activation of the androgen receptor.Clinical & experimental metastasis · 2004Article
- Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases.Clinical & experimental metastasis · 2003Article
- Ribozyme-targeting of a secreted FGF-binding protein (FGF-BP) inhibits proliferation of prostate cancer cells in vitro and in vivo.Oncogene · 2002Article
- Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor.The American journal of pathology · 1999Article
- A novel spontaneous metastasis model of human osteosarcoma developed using orthotopic transplantation of intact tumor tissue into tibia of nude mice.Clinical & experimental metastasis · 1997Article
- Establishment of a hepatocyte cell line producing growth-promoting factors for liver-colonizing tumor cells.Japanese journal of cancer research : Gann · 1996Article
- Proliferation of osteoclast-like giant cells in a metastatic bone tumor from stomach cancer: report of a case and analysis of the autopsy findings.Surgery today · 1996Article
- The establishment of two cell lines from a mouse uterine cervical carcinoma (U14) and their metastatic phenotype changes.Clinical & experimental metastasis · 1995Article
- Spinal cord compression in prostate cancer.Journal of neuro-oncology · 1995Review
- Inhibition of tumor growth by elimination of granulocytes.The Journal of experimental medicine · 1995Article
- Prostate cancer progression. Implications of histopathology.The American journal of pathology · 1994Review
- Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis.Cancer metastasis reviews · 1993Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Malignant prostatic carcinoma, a major cause of cancer mortality in males, most often metastasizes to secondary sites in bone. Frequently, the growth rate of the secondary tumor in bone marrow is considerably greater than that of the slowly growing primary prostatic tumor. We now report that two lines of human prostatic carcinoma cells proliferate in response to conditioned media from unstimulated human, rat, or bovine bone marrow. Nonprostatic tumor cell lines showed little or no growth response to the same medium. The proliferative activity found in bone marrow was not duplicated by any of a variety of purified growth factors including epidermal growth factor (EGF), acidic or basic fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF) alpha or beta, interleukins 1, 2, 3, 4 or 6, granulocyte (G), macrophage (M) or granulocyte-macrophage (GM) colony stimulating factor (CSF). Whereas a mixture of G-CSF, M-CSF, and IL 3 produced a mitogenic response in the prostatic carcinoma cells, these three factors were not present in our bone marrow samples in sufficient quantities to promote the observed proliferative response. To further identify the cellular source of the proliferative activity present in bone marrow-conditioned medium, we tested conditioned media made from human bone marrow stromal cells. The stromal cell conditioned medium stimulated increased growth of the prostatic carcinoma cells to levels equivalent to those observed with the bone marrow conditioned medium. These results suggest that novel mitogenic factors that are produced by bone marrow stromal cells and remain in the bone marrow cavity may account, in part, for the preferential growth of prostatic metastases in bone.
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