ArticleJournal of abnormal psychology2017
Startle potentiation to uncertain threat as a psychophysiological indicator of fear-based psychopathology: An examination across multiple internalizing disorders.
Article in Journal of abnormal psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 133 citations in OpenAlex.
- Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety.Translational psychiatry · 2022Trial
- The Effect of Music Therapy in Reducing Dental Anxiety and Lowering Physiological Stressors.Acta bio-medica : Atenei Parmensis · 2022Trial
- The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.Psychopharmacology · 2021Trial
- Impact of Childhood Family Conflict on Adolescents' Startle Reactivity to Threat: The Moderating Role of Sensory Processing Sensitivity.Journal of adolescence · 2026Article
- Psychosocial impacts of a mouse plague and ongoing psychological stress.Scientific reports · 2026Article
- Reply to Lago, T.R.; Bolognani, F. Comment on "Nazarloo et al. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2026Article
- Comment on Nazarloo et al. Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2026Article
- Disorganized Striatal Functional Connectivity as a Partially Shared Pathophysiological Mechanism in Both Schizophrenia and Major Depressive Disorder: A Transdiagnostic fMRI Study.Brain topography · 2025Article
- Impact of behavioral inhibitory control and startle reactivity to uncertain threat on youth suicide risk.Psychophysiology · 2025Article
- The Intersection of Interoception and Anticipation Related to Pain.Current topics in behavioral neurosciences · 2025Review
- Expectation of pain and relief: A dynamical model of the neural basis for pain-trauma co-morbidity.Neuroscience and biobehavioral reviews · 2024Review
- Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Sleep quality impacts the link between reactivity to uncertain threat and anxiety and alcohol use in youth.Psychophysiology · 2024Article
- Normalizing Uncertain Threat: What Change in Anxiety-Potentiated Startle Can Tell Us About Anxiety Treatment.Biological psychiatry · 2024Article
- Transdiagnostic Fear and Anxiety: Prospective Prediction Using the No-Threat, Predictable Threat, and Unpredictable Threat Task.Biological psychiatry global open science · 2023Article
- Threat effects on cognitive systems: Testing links to aggression proneness.Emotion (Washington, D.C.) · 2023Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Family study of the startle reflex and event-related potentials in anticipation of predictable and unpredictable threat in adolescents and their parents.Psychophysiology · 2023Article
- Don't worry, it won't be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation.Cognitive, affective & behavioral neuroscience · 2023Article
- A proof-of-concept randomized crossover clinical trial of a first-in-class vasopressin 1a receptor antagonist for PTSD: Design, methods, and recruitment.Contemporary clinical trials communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Heightened reactivity to uncertain threat (U-threat) is an important individual difference factor that may characterize fear-based internalizing psychopathologies (IPs) and distinguish them from distress/misery IPs. To date, however, the majority of existing research examining reactivity to U-threat has been within individuals with panic disorder and major depressive disorder (MDD) and no prior study has directly tested this hypothesis across multiple IPs. The current study therefore explored whether heightened reactivity to U-threat is a psychophysiological indicator of fear-based psychopathology across 5 groups: current (a) social anxiety disorder (SAD); (b) specific phobia (SP); (c) generalized anxiety disorder (GAD); (d) MDD; and (c) individuals with no history of psychopathology (controls). All 160 adults completed a well-validated threat-of-shock task designed to probe responses to predictable (P-) and U-threat. Startle eyeblink potentiation was recorded as an index of aversive arousal. Results indicated that individuals with SAD and SP evidenced greater startle potentiation to U-threat, but not P-threat, relative to individuals with GAD, MDD, and controls (who did not differ). The current findings, along with the prior panic disorder and MDD literature, suggest that heightened reactivity to U-threat is a psychophysiological indicator of fear-based disorders and could represent a neurobiological organizing principle for internalizing psychopathology. The findings also suggest that individuals with fear disorders generally display a hypersensitivity to uncertain aversive events, which could contribute to their psychopathology. (PsycINFO Database Record
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.