Evidence map›Paper›PMID 27868084›Full record

ArticleBone reports2016

The association between bone turnover markers and kyphosis in community-dwelling older adults.

Corinne R McDaniels-Davidson, Donna Kritz-Silverstein, Mei-Hua Huang, Gail A Laughlin, Sarah Johnson, Jouko Haapalahti, Diane L Schneider, Elizabeth Barrett-Connor, Deborah M Kado

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Bone reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Corinne R McDaniels-DavidsonSan Diego State University/University of California, San Diego Joint Doctoral Program in Public Health (Epidemiology), 9500 Gilman Drive, MC 0725, La Jolla, CA 92093, United States.
Donna Kritz-SilversteinDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United States.
Mei-Hua HuangDepartment of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Gail A LaughlinDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United States.
Sarah JohnsonSPD Development Company Limited, Bedford, UK.
Jouko HaapalahtiJouZeNet Consulting Limited, Kempele, Finland.
Diane L Schneider4BoneHealth, La Jolla, CA, United States.
Elizabeth Barrett-ConnorDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United States.
Deborah M KadoDepartment of Family Medicine and Public Health, University of California, San Diego School of Medicine, San Diego, CA, United States.
University of California San Diego · USFinnish Consulting Group (Finland) · FISan Diego State University · USUniversity of California, Los Angeles · US

Funding

STUDY OF RISK FACTORS FOR OSTEOPOROSIS IN THE ELDERLYR37AG007181 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1987 to 2010
$5.4M
GENDER DIFFERENCES IN OSTEOPOROSISR01AG007181 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1999 to 2002
$1.6M
BIOLOGICAL AND STRUCTURAL PREDICTORS OF KYPHOSIS PROGRESSION IN OLDER MENR01AR060828 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2011 to 2013
$1.0M
NIAMS NIH HHS R01 AR060828NIA NIH HHS R01 AG007181NIA NIH HHS R37 AG007181
6 · The paper itself

Abstract

purposeHyperkyphosis, accentuated curvature of the thoracic spine, is often attributed to osteoporosis, yet its underlying pathophysiology is not well understood. Bone turnover markers (BTM) reflect the dynamic process of bone formation and resorption. This study examined the association between serum BTM levels and kyphosis in community-dwelling older adults.

methodsBetween 2003 and 2006, 760 men and women in the Rancho Bernardo Study age 60 and older had blood drawn and kyphosis measured. Fasting serum was assayed for N-telopeptide (NTX) and procollagen type 1 n-terminal propeptide (P1NP), markers of bone resorption and formation, respectively. Participants requiring two or more 1.7 cm blocks under their head to achieve a neutral supine position were classified as having accentuated kyphosis. Analyses were stratified by sex and use of estrogen therapy (ET). Odds of accentuated kyphosis were calculated for each standard deviation increase in log-transformed BTM.

resultsMean age was 75 years. Overall, 51% of 341 non-ET using women, 41% of 111 ET-using women, and 75% of 308 men had accentuated kyphosis. In adjusted models, higher P1NP and NTX were associated with decreased odds of accentuated kyphosis in non-ET using women (P1NP: OR = 0.78 [95% CI, 0.58-0.92]; NTX: OR = 0.68 [95% CI, 0.54-0.86]), but not in men or ET-using women (

conclusionsThe selective association of higher bone turnover with reduced odds of accentuated kyphosis in non-ET using women suggests that elevated BTM were associated with a lower likelihood of hyperkyphosis only in the low estrogen/high BTM environment characteristic of postmenopausal women who are not using ET.

Indexed as

Bone remodelingBone turnoverBTM, bone turnover markersET, estrogen therapyHyperkyphosisKyphosisNTXNTX, N-telopeptideP1NPP1NP, procollagen type 1 n-terminal propeptideSOF, Study of Osteoporotic Fractures

Identifiers

PMID27868084
PMCPMC4926834
OpenAlexW2331959438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.