Evidence map›Paper›PMID 27867960›Full record

ArticleAnnals of translational medicine2016

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials.

Gregory A Chinn, Jennifer M Sasaki Russell, Jeffrey W Sall

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Anesthesia for fetal operative procedures: A systematic review.Frontiers in pain research (Lausanne, Switzerland) · 2022
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gregory A ChinnDepartment of Anesthesiology, University of California, San Francisco, CA, USA.
Jennifer M Sasaki RussellDepartment of Anesthesiology, University of California, San Francisco, CA, USA.
Jeffrey W SallDepartment of Anesthesiology, University of California, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Testosterone's role in sex-specific outcomes after early anesthesiaR01GM112831 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALL, JEFFREY W · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM112831
6 · The paper itself

Abstract

Early life exposure to general anesthesia in preclinical studies has consistently led to permanent cognitive deficits later in life. However, the extent to which this finding is translatable to humans is the subject of much debate as the results from clinical studies have been mixed. Recently two well-designed clinical trials have attempted to add clarity to our murky understanding. The General Anesthesia compared to Spinal anesthesia (GAS) trial, was an international, prospective, randomized, multicenter, equivalence trial comparing infants undergoing herniorrhaphy receiving general anesthesia

Indexed as

cognitive impairmentEarly anesthesianeurotoxicitypediatric anesthesiaRCT

Identifiers

PMID27867960
PMCPMC5107408
OpenAlexW2541678073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.