ArticleBrain tumor research and treatment2016
Therapeutic Strategy for Cavernous Sinus-Invading Non-Functioning Pituitary Adenomas Based on the Modified Knosp Grading System.
Article in Brain tumor research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- [Matrix metalloproteinases in pituitary adenoma invasiveness].Problemy endokrinologii · 2026Review
- Feasibility study of the concepts of 360° access to the cavernous sinus in endoscopic biportal (transorbital and endonasal) surgery for invasive pituitary adenomas: Cadaveric anatomy, surgical nuances, and case illustrations.Surgical neurology international · 2026Article
- Risk factors and prognosis of visual and cranial nerve deficits in patients operated for pituitary tumor - with a focus on intrasellar pressure.Acta neurochirurgica · 2025Article
- Management of Recurrent and Aggressive Non-Functioning Pituitary Adenomas.Journal of clinical medicine · 2025Review
- Clinicopathological analysis of non-functioning pituitary adenomas (PAs) according to the 2022 WHO classification.Pituitary · 2024Article
- Update on Current Evidence for the Diagnosis and Management of Nonfunctioning Pituitary Neuroendocrine Tumors.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Intrasellar pressure in patients with pituitary adenoma - relation to tumour size and growth pattern.BMC neurology · 2022Article
- Neuroimaging of paediatric pineal, sellar and suprasellar tumours: a guide to differential diagnosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Classification of Pituitary Adenomas Invading the Cavernous Sinus Assisted by Three-Dimensional Multimodal Imaging and Its Clinical Application.Journal of neurological surgery. Part B, Skull base · 2021Article
- Clinical relevance of tumor consistency in pituitary adenoma.Hormones (Athens, Greece) · 2021Review
- Radiological Knosp, Revised-Knosp, and Hardy-Wilson Classifications for the Prediction of Surgical Outcomes in the Endoscopic Endonasal Surgery of Pituitary Adenomas: Study of 228 Cases.Frontiers in oncology · 2021Article
- Outcomes and Complications of Aggressive Resection Strategy for Pituitary Adenomas in Knosp Grade 4 With Transsphenoidal Endoscopy.Frontiers in oncology · 2021Article
- Review
- Predictive modeling for pituitary adenomas: single center experience in 501 consecutive patients.Pituitary · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-functioning pituitary adenomas (NFPA) invading into the cavernous sinus are surgically challenging. To decrease recurrence rate, surgeon makes a strong endeavor to resect tumor gross totally. However, gross total resection (GTR) is difficult to achieve with cavernous sinus invasion. Recently, a new classification system for cavernous invasion of pituitary adenomas was suggested. The aim of this study is to validate this new classification system and to identify limitations and considerations in designing treatment strategies for patients with NFPA involving the cavernous sinus.
methodsBetween January 2000 and January 2012, 275 patients who underwent operation for NFPA were enrolled in the study. Median age was 50 years (15-79 years). There were 145 males and 130 females. The median follow-up duration was 4 years (range 1-12.5 years).
resultsRelated to extent of tumor removal, GTR was obtained in 184 patients (66.9%), near total resection (NTR) was obtained in 45 patients (16.3%), and sub-total resection (STR) was obtained in 46 patients (16.7%) of a total 275 patients. There were statistically significant differences between the extent of resection and the new Knosp classification (
conclusionIn case of high risk of surgical complications, STR with adjuvant radiation therapy can be considered as an alternative strategy for safe treatment of cavernous-invading adenomas.
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