ReviewGland surgery2016
Early intact PTH (iPTH) is an early predictor of postoperative hypocalcemia for a safer and earlier hospital discharge: an analysis on 260 total thyroidectomies.
Review in Gland surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Definition and diagnosis of postsurgical hypoparathyroidism after thyroid surgery: meta-analysis.BJS open · 2022Pooled it
- Postoperative Hypocalcemia Following Total Thyroidectomy Versus Completion Thyroidectomy.The Laryngoscope · 2026Article
- A blood-draw timing- and season-adjusted PTH-calcium model for predicting post-endoscopic/robotic thyroidectomy hypocalcemia.Endocrine connections · 2026Article
- Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.Medicina (Kaunas, Lithuania) · 2026Article
- Predicting Hypocalcemia and Identifying Supplementation Needs After Total Thyroidectomy: The Role of Perioperative PTH Measurements.Biomedicines · 2025Article
- Analysis of risk factors and development of a risk prediction model for postoperative hypocalcemia in differentiated thyroid cancer.American journal of cancer research · 2025Article
- Early Postoperative Parathormone and Calcium as Prognostic Factors for Postoperative Hypocalcemia.Journal of clinical medicine · 2022Article
- Intraoperative Indocyanine Green Angiography of Parathyroid Glands and the Prevention of Post-Thyroidectomy Hypocalcemia.World journal of surgery · 2022Article
- Role of postoperative intact serum PTH as an early predictor of severe post-thyroidectomy hypocalcemia: a prospective study.Journal of endocrinological investigation · 2021Article
- The role of early postoperative parathyroid hormone level after total thyroidectomy in prediction of hypocalcemia.Annals of medicine and surgery (2012) · 2021Article
- Short-term recovery in patients suffering hypoparathyroid after thyroidectomy: a case control study.BMC surgery · 2021Article
- Rate of drop in serum calcium as a predictor of hypocalcemic symptoms post total thyroidectomy.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Effect of nerve monitoring on complications of thyroid surgery.Northern clinics of Istanbul · 2018Article
- Short and long-term impact of parathyroid autotransplantation on parathyroid function after total thyroidectomy.Gland surgery · 2017Review
- Recent developments in the follow-up, prevention and management of complications in thyroid surgery.Gland surgery · 2017Article
- Serum phosphorus values for early prediction of hypocalcemia in total thyroidectomy.Gland surgery · 2017Article
- IPTH cost-effectiveness in thyroid surgery.Gland surgery · 2017Article
- New techniques and technologies for the treatment of surgical endocrine diseases.Gland surgery · 2016Article
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Authors and funding
11 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypocalcemia is the most frequent complication after thyroidectomy. Serum calcium levels are reliable only 48-72 hours postoperatively. Early intact PTH (iPTH) has been proposed as early predictor of postoperative hypocalcemia. Our aim is to assess the ability of iPTH in predicting postoperative hypocalcemia.
methodsTwo hundred and sixty patients underwent thyroidectomy with postoperative iPTH evaluation. The iPTH samplings were early performed after thyroidectomy. The calcium levels were dosed postoperatively. Age, sex, clinical diagnosis, obesity, comorbidities, previous neck surgery, preoperative therapy, type of surgery, dissectors used, lymphadenectomy, post-operative complications, reoperation and histological diagnosis were considered. The primary end-point was the postoperative hospital stay. The secondary end-points were serum calcium and iPTH. Three iPTH cut-offs were tested to assess which was the best value (10.0, 15.0, and 20.0 pg/mL).
resultsThe iPTH cut-off value of 10.0 pg/mL was the most accurate and specific for hypocalcemia. Comparing the iPTH value with the different values of calcium respectively 24 and 48 hours after surgery, a statistically stronger association with the serum calcium levels 48 hours postoperatively has been shown. iPTH ≥10 pg/mL 3-6 hours after surgery was strongly correlated to early discharge.
conclusionsThe correlation of iPTH with hypocalcemia is significant since a few hours after surgery and the value of iPTH ≥10 pg/mL is able to select those patients for a safe and early discharge. The use of the iPTH might avoid unnecessary extensions of hospitalization.
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