ArticleBiomedical optics express2016
Adaptive illumination reduces photobleaching in structured illumination microscopy.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Noise Sources and Strategies for Signal Quality Improvement in Biological Imaging: A Review Focused on Calcium and Cell Membrane Voltage Imaging.Biosensors · 2026Review
- Adaptive fluorescence lifetime imaging with per-pixel signal optimization and flexible scanning.Biomedical optics express · 2025Article
- Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging.Nature communications · 2025Article
- Live-cell imaging powered by computation.Nature reviews. Molecular cell biology · 2024Review
- Light-sheets and smart microscopy, an exciting future is dawning.Communications biology · 2023Review
- Event-driven acquisition for content-enriched microscopy.Nature methods · 2022Article
- An adaptive microscope for the imaging of biological surfaces.Light, science & applications · 2021Article
- Simulating digital micromirror devices for patterning coherent excitation light in structured illumination microscopy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Between life and death: strategies to reduce phototoxicity in super-resolution microscopy.Journal of physics D: Applied physics · 2020Review
- Video-rate volumetric neuronal imaging using 3D targeted illumination.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photobleaching is a major factor limiting the observation time in fluorescence microscopy. We achieve photobleaching reduction in structured illumination microscopy (SIM) by locally adjusting the illumination intensities according to the sample. Adaptive SIM is enabled by a digital micro-mirror device (DMD), which provides a projection of the grayscale illumination patterns. We demonstrate a reduction in photobleaching by a factor of three in adaptive SIM compared to the non-adaptive SIM based on a spot grid scanning approach. Our proof-of-principle experiments show great potential for DMD-based microscopes to become a more useful tool in live-cell SIM imaging.
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Registered trials
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