ArticleBiomedical optics express2016
Label free measurement of retinal blood cell flux, velocity, hematocrit and capillary width in the living mouse eye.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 77 citations in OpenAlex.
- Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling.Nature biomedical engineering · 2026Article
- Automated montaging and contrast stretching of adaptive optics ophthalmoscope images.Biomedical optics express · 2026Article
- Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner.Biomedical optics express · 2026Article
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
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- Photoreceptor loss does not recruit neutrophils despite strong microglial activation.bioRxiv : the preprint server for biology · 2025Article
- A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks.Investigative ophthalmology & visual science · 2024Article
- In Vivo Visualization of Intravascular Patrolling Immune Cells in the Primate Eye.Investigative ophthalmology & visual science · 2024Article
- Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.Biomedical optics express · 2024Article
- High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.Biomedical optics express · 2024Article
- Validation of an automated method for studying retinal capillary blood flow.Biomedical optics express · 2024Article
- Changes to the shape, orientation and packing of red cells as a function of retinal capillary size.Biomedical optics express · 2024Article
- Flow Heterogeneity and Factors Contributing to the Variability in Retinal Capillary Blood Flow.Investigative ophthalmology & visual science · 2023Article
- Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion.Neurophotonics · 2023Article
- High-resolution structural and functional retinal imaging in the awake behaving mouse.Communications biology · 2023Article
- High-speed measurement of retinal arterial blood flow in the living human eye with adaptive optics ophthalmoscopy.Optics letters · 2023Article
- Introduction to the Feature Issue on Adaptive Optics for Biomedical Applications.Biomedical optics express · 2023Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Measuring blood cell dynamics within the capillaries of the living eye provides crucial information regarding the health of the microvascular network. To date, the study of single blood cell movement in this network has been obscured by optical aberrations, hindered by weak optical contrast, and often required injection of exogenous fluorescent dyes to perform measurements. Here we present a new strategy to non-invasively image single blood cells in the living mouse eye without contrast agents. Eye aberrations were corrected with an adaptive optics camera coupled with a fast, 15 kHz scanned beam orthogonal to a capillary of interest. Blood cells were imaged as they flowed past a near infrared imaging beam to which the eye is relatively insensitive. Optical contrast of cells was optimized using differential scatter of blood cells in the split-detector imaging configuration. Combined, these strategies provide label-free, non-invasive imaging of blood cells in the retina as they travel in single file in capillaries, enabling determination of cell flux, morphology, class, velocity, and rheology at the single cell level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.