ArticleBiomedical optics express2016
Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Effective transfer of tumor annotations from hematoxylin and eosin to fluorescence images of breast and lung tissues.Journal of biomedical optics · 2026Article
- Two-step regression analysis approach to assess burn wound severity using spatial frequency domain imaging.Journal of biomedical optics · 2026Article
- Structured light radial-view endoscope PROBE for IMAGING of colorectal tissue.Optics letters · 2025Article
- Deep-learning-enabled spatial frequency domain imaging of the spatiotemporal dynamics of skin physiology.Journal of biomedical optics · 2025Article
- Monte Carlo simulation of spatial frequency domain imaging for breast tumors during compression.Journal of biomedical optics · 2024Article
- Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring.Journal of biomedical optics · 2023Article
- Designing and simulating realistic spatial frequency domain imaging systems using open-source 3D rendering software.Biomedical optics express · 2023Article
- Spatial frequency domain imaging for the assessment of scleroderma skin involvement.Biomedical optics express · 2023Article
- Quantitative spatial mapping of tissue water and lipid content using spatial frequency domain imaging in the 900- to 1000-nm wavelength region.Journal of biomedical optics · 2022Article
- Training generative adversarial networks for optical property mapping using synthetic image data.Biomedical optics express · 2022Article
- Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties.Journal of biomedical optics · 2022Article
- [An optical parameter imaging system with profile information fusion].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model.Scientific reports · 2022Article
- Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine breast cancer.Cancer research communications · 2022Article
- Two-layer analytical model for estimation of layer thickness and flow using Diffuse Correlation Spectroscopy.PloS one · 2022Article
- Imaging sub-diffuse optical properties of cancerous and normal skin tissue using machine learning-aided spatial frequency domain imaging.Journal of biomedical optics · 2021Article
- Speckle illumination SFDI for projector-free optical property mapping.Optics letters · 2021Article
- Direct mapping from diffuse reflectance to chromophore concentrations in multi-Biomedical optics express · 2021Article
- Rapid tissue oxygenation mapping from snapshot structured-light images with adversarial deep learning.Journal of biomedical optics · 2020Article
- Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content.Nature communications · 2020Article
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6 authors.
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Abstract
Determination of chemotherapy efficacy early during treatment would provide more opportunities for physicians to alter and adapt treatment plans. Diffuse optical technologies may be ideally suited to track early biological events following chemotherapy administration due to low cost and high information content. We evaluated the use of spatial frequency domain imaging (SFDI) to characterize a small animal tumor model in order to move towards the goal of endogenous optical monitoring of cancer therapy in a controlled preclinical setting. The effects of key measurement parameters including the choice of imaging spatial frequency and the repeatability of measurements were evaluated. The precision of SFDI optical property extractions over repeat mouse measurements was determined to be within 3.52% for move and replace experiments. Baseline optical properties and chromophore values as well as intratumor heterogeneity were evaluated over 25 tumors. Additionally, tumor growth and chemotherapy response were monitored over a 45 day longitudinal study in a small number of mice to demonstrate the ability of SFDI to track treatment effects. Optical scattering and oxygen saturation increased as much as 70% and 25% respectively in treated tumors, suggesting SFDI may be useful for preclinical tracking of cancer therapies.
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