Evidence map›Paper›PMID 27867720›Full record

ArticleBiomedical optics express2016

Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods.

Yanjie Wang, Eric M Strohm, Yang Sun, Zhaoxia Wang, Yuanyi Zheng, Zhigang Wang, Michael C Kolios

Abstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. PLGA-Based Composites for Various Biomedical Applications.International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Photoacoustic Drug Delivery.Sensors (Basel, Switzerland) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanjie WangPhysics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
Eric M StrohmPhysics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
Yang SunInstitute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Rd., Chongqing, 400010, China.
Zhaoxia WangDepartment of Ultrasound, Children's Hospital, Affiliated to Chongqing Medical University, No.136, Zhongshan No.2 Rd., Yuzhong District, Chongqing 400014, China.
Yuanyi ZhengUltrasound Department, Sixth affiliated hospital of Shanghai Jiaotong University, 600 Yishan Rd., Xuhui District, Shanghai, 200133, China.
Zhigang WangInstitute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Rd., Chongqing, 400010, China.
Michael C KoliosPhysics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, optical-triggered multifunctional theranostic agents for photoacoustic/fluorescent imaging and cancer therapy have been developed. This system consists of a perfluorohexane liquid and gold nanoparticles (GNPs) in the core, stabilized by a Poly (lactide-co-glycolic acid) (PLGA) polymer shell. When cancer cells containing PLGA-GNPs were exposed to laser pulses, cell viability decreased due to the vaporization of the particles in and around the cells. The particle chemo drug loading and delivery capacity was also investigated in vitro experiments. These particles show potential as photoacoustic imaging and therapy agents for future clinical translation in cancer therapy.

Indexed as

(160.1435) Biomaterials(160.4236) Nanomaterials(170.2520) Fluorescence microscopy(170.3880) Medical and biological imaging(170.5120) Photoacoustic imaging

Identifiers

PMID27867720
PMCPMC5102552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.