Evidence map›Paper›PMID 27867719›Full record

ArticleBiomedical optics express2016

Monitoring cerebral oxygenation and local field potential with a variation of isoflurane concentration in a rat model.

Dong-Hyuk Choi, Teo Jeon Shin, Seonghyun Kim, Jayyoung Bae, Dongrae Cho, Jinsil Ham, Ji-Young Park, Hyoung-Ihl Kim, Seongwook Jeong, Boreom Lee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Dong-Hyuk ChoiDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea; These authors contributed equally to this study.
Teo Jeon ShinDepartment of Pediatric Dentistry, School of Dentistry, Seoul National University, Seoul 03080, South Korea; These authors contributed equally to this study.
Seonghyun KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
Jayyoung BaeDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
Dongrae ChoDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
Jinsil HamDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
Ji-Young ParkDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
Hyoung-Ihl KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea.
Seongwook JeongDepartment of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju 61469, South Korea.
Boreom LeeDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea; leebr@gist.ac.kr.
Jae Gwan KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea; jaekim@gist.ac.kr.
Gwangju Institute of Science and Technology · KRChonnam National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate experimentally how anesthetic levels affect cerebral metabolism measured by near-infrared spectroscopy (NIRS) and to identify a robust marker among NIRS parameters to discriminate various stages of anesthetic depth in rats under isoflurane anesthesia. In order to record the hemodynamic changes and local field potential (LFP) in the brain, fiber-optic cannulae and custom-made microelectrodes were implanted in the frontal cortex of the skull. The NIRS and LFP signals were continuously monitored before, during and after isoflurane anesthesia. As isoflurane concentration is reduced, the level of oxyhemoglobin and total hemoglobin concentrations of the frontal cortex decreased gradually, while deoxyhemoglobin increased. The reflectance ratio between 730nm and 850nm and burst suppression ratio (BSR) correspond similarly with the change of oxyhemoglobin during the variation of isoflurane concentration. These results suggest that NIRS signals in addition to EEG may provide a possibility of developing a new anesthetic depth index.

Indexed as

(000.1430) Biology and medicine(170.1460) Blood gas monitoring(170.2655) Functional monitoring and imaging(170.4580) Optical diagnostics for medicine

Identifiers

PMID27867719
PMCPMC5102553
OpenAlexW2519419674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.