Evidence map›Paper›PMID 27867689›Full record

ArticleWorld journal of gastrointestinal pharmacology and therapeutics2016

Family history and disease outcomes in patients with Crohn's disease: A comparison between China and the United States.

Pei-Qi Wang, Jun Hu, Elie S Al Kazzi, Eboselume Akhuemonkhan, Min Zhi, Xiang Gao, Raquel Holand de Paula Pessoa, Sami Ghazaleh, Tuhina Cornelius, Suhel Abbas Sabunwala and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal pharmacology and therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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  11. Risk factors for inflammatory bowel disease: A prospective multi-center study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Pei-Qi WangPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Jun HuPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Elie S Al KazziPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Eboselume AkhuemonkhanPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Min ZhiPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Xiang GaoPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Raquel Holand de Paula PessoaPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Sami GhazalehPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Tuhina CorneliusPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Suhel Abbas SabunwalaPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Shadi GhadermarziPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Kartikeya TripathiPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Mark LazarevPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Pin-Jin HuPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Susan HutflessPei-Qi Wang, Eboselume Akhuemonkhan, Shadi Ghadermarzi, Mark Lazarev, Susan Hutfless, Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States.
Johns Hopkins University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
NCATS NIH HHS UL1 TR001079
6 · The paper itself

Abstract

aimTo investigate the differences in family history of inflammatory bowel disease (IBD) and clinical outcomes among individuals with Crohn's disease (CD) residing in China and the United States.

methodsWe performed a survey-based cross-sectional study of participants with CD recruited from China and the United States. We compared the prevalence of IBD family history and history of ileal involvement, CD-related surgeries and IBD medications in China and the United States, adjusting for potential confounders.

resultsWe recruited 49 participants from China and 145 from the United States. The prevalence of family history of IBD was significantly lower in China compared with the United States (China: 4.1%, United States: 39.3%). The three most commonly affected types of relatives were cousin, sibling, and parent in the United States compared with child and sibling in China. Ileal involvement (China: 63.3%, United States: 63.5%) and surgery for CD (China: 51.0%, United States: 49.7%) were nearly equivalent in the two countries.

conclusionThe lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States. Despite the potential difference in etiology, surgery and ileal involvement were similar in the two countries. Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.

Indexed as

Crohn’s diseaseDisease outcomeEnvironmentEpidemiologyFamily historygeneticsInflammatory bowel diseaseMedicationSurgery

Identifiers

PMID27867689
PMCPMC5095575
OpenAlexW2545556066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.