ArticleJournal of thoracic disease2016
Clinicopathological features and prognosis of patients <45 years old with esophageal adenocarcinoma comparing to other age groups.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Survival outcomes in early-onset oesophageal adenocarcinoma patients: A systematic review and meta-analyses.World journal of gastroenterology · 2024Pooled it
- Article
- Development and validation of nomogram models to predict radiotherapy or chemotherapy benefit in stage III/IV gastric adenocarcinoma with surgery.Frontiers in oncology · 2023Article
- Construction and verification of prognostic nomogram for early-onset esophageal cancer.Bosnian journal of basic medical sciences · 2021Article
- Outcomes of curative esophageal cancer surgery in elderly: A meta-analysis.World journal of gastrointestinal oncology · 2021Article
- Is the age of diagnosis of esophageal adenocarcinoma getting younger? Analysis at a tertiary care center.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2020Article
- Clinical characteristics of young patients with early Barrett's neoplasia.World journal of gastroenterology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo analyze the clinicopathological features and prognosis of younger patients with esophageal adenocarcinoma (EAC).
methodsA total of 2,601 patients diagnosed with EAC between 1988 and 2011 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. All patients underwent primary tumor resection and regional lymphadenectomy without preoperative radiotherapy. The patients were into four age groups (<45, 45-59, 60-74, ≥75), with 94, 813, 1,272 and 422 patients in each group respectively.
resultsPatients in the age <45 group were more likely to have lymph node (LN) metastasis (P=0.002), postoperative radiotherapy (P<0.001) and advanced T and N stage (P=0.003, 0.014) compared to the other three groups. We then conducted two Cox proportional hazards model adjusted for the sex, race, number of LNs examined, histological grade, postoperative radiation. The hazard ratio (HR) was higher in patients <45 y and the survival rate were paradoxically lower compared to the patients between 45-60 years old (P=0.046, 0.039).
conclusionsThe patients <45 y had the most aggressive clinicopathological features of EAC and poorer survival rate after radical esophagectomy.
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