ArticleJournal of thoracic disease2016
A morphologic study of the airway structure abnormalities in patients with asthma by high-resolution computed tomography.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Clinical features of asthma with comorbid bronchiectasis: A systematic review and meta-analysis.Medicine · 2021Pooled it
- [Asthma and heroin use].Presse medicale (Paris, France : 1983)Pooled it
- The role of radiological imaging in the management of severe and difficult-to-treat asthma.Breathe (Sheffield, England) · 2024Review
- The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma.International journal of molecular sciences · 2024Review
- Endobronchial optical coherence tomography or computed tomography for evaluating progression of bronchiectasis.ERJ open research · 2023Article
- Relationships Between High-Resolution Computed Tomographic Features and Lung Function Trajectory in Patients With Asthma.Allergy, asthma & immunology research · 2023Article
- Risk factors for the development of bronchiectasis in patients with asthma.Scientific reports · 2021Article
- Ultra-high-resolution computed tomography shows changes in the lungs related with airway hyperresponsiveness in a murine asthma model.Scientific reports · 2021Article
- Differences in the Clinical Characteristics of Early- and Late-Onset Asthma in Elderly Patients.BioMed research international · 2020Article
- An association between pulmonary Mycobacterium avium-intracellulare complex infections and biomarkers of Th2-type inflammation.Respiratory research · 2017Article
- Bronchiectasis and increased mortality in patients with corticosteroid-dependent severe asthma: a nationwide population study.Therapeutic advances in respiratory diseaseArticle
- Longitudinal Evaluation of Chronic Rhinosinusitis Symptoms in a Population-Based Sample.The journal of allergy and clinical immunology. In practiceArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAirway structure changes, termed as airway remodeling, are common in asthma patients due to chronic inflammation, which can be assessed by high-resolution computed tomography (HRCT). Considering the controversial conclusions in the correlation of morphologic abnormalities with clinical feature and outcome, we aimed to further specify and evaluate the structural abnormalities of Chinese asthmatics by HRCT.
methodsFrom August 2012 to February 2015, outpatients with asthma were recruited consecutively in the Asthma Center of West China Hospital, Sichuan University. Standard HRCT and pulmonary function test (PFT) were performed to collect information of bronchial wall thickening, bronchial dilatation, mucus impaction, emphysema, mosaic perfusion, atelectasis, and spirometric parameters. We reported the incidence of each structural abnormality in HRCT and compared it among different asthmatic severities.
resultsA total of 123 asthmatics were enrolled, among which 84 (68.3%) were female and 39 (31.7%) were male. At least one structural abnormality was detected by HRCT in 85.4% asthmatics, and the incidence of bronchial wall thickening, bronchial dilatation, mucus impaction, emphysema, mosaic perfusion, and atelectasis was 57.7%, 51.2%, 22%, 24.4%, 5.7% and 1.6%, respectively. The incidences of bronchial wall thickening, bronchial dilation and emphysema were significantly increased by asthma severity (P<0.05), while incidences of mucus impaction (26/27, 96.30%), mosaic perfusion (6/7, 85.71%) and atelectasis (2/2, 100%) were mainly found in severe asthma. We found a longer asthma history (28.13±18.55 years, P<0.001, P=0.003), older age (51.30±10.70 years, P=0.022, P=0.006) and lower predicted percentage of forced expiratory volume in one second (FEV
conclusionsThe incidences of structural abnormalities detected by HRCT are fairly high in Chinese asthma populations, especially the bronchial wall thickening and bronchial dilation, which are significantly increased in severe asthma, and are potential risk factors of pulmonary function decline in asthmatics.
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