ReviewMedical gas research
Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective.
Review in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04144868 (Normobaric Hyperoxia for Intracerebral Hemorrhage A Randomized Clinical Trial), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Normobaric Hyperoxia for Intracerebral Hemorrhage A Randomized Clinical Trial
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Adjuvant High-Flow Normobaric Oxygen After Mechanical Thrombectomy for Anterior Circulation Stroke: a Randomized Clinical Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Trial
- Relationship between Preoperative and Postoperative Peripheral Oxygen Saturation and Malignant Brain Edema in Stroke Patients Undergoing Mechanical Thrombectomy.Current neurovascular research · 2025Article
- Opportunities for Neuroprotective Drugs in the Era of Vascular Recanalization.Translational stroke research · 2024Article
- Review
- Neuroprotection during Thrombectomy for Acute Ischemic Stroke: A Review of Future Therapies.International journal of molecular sciences · 2024Review
- The BE COOL Treatments (Batroxobin, oxygEn, Conditioning, and cOOLing): Emerging Adjunct Therapies for Ischemic Cerebrovascular Disease.Journal of clinical medicine · 2022Review
- Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes.CNS neuroscience & therapeutics · 2022Article
- Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions.Progress in lipid research · 2022Review
- Oxygen saturation before and after mechanical thrombectomy and functional outcome in patients with acute ischemic stroke.Frontiers in cardiovascular medicine · 2022Article
- A Review of Low-Frequency EPR Technology for the Measurement of Brain pO2 and Oxidative Stress.Applied magnetic resonance · 2021Article
- Biological effects of the oxygen molecule in critically ill patients.Journal of intensive care · 2020Review
- Review
- Normobaric oxygen inhibits AQP4 and NHE1 expression in experimental focal ischemic stroke.International journal of molecular medicine · 2019Article
- Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats.Journal of neurophysiology · 2018Article
- [Intensive care studies from 2017/2018].Der Anaesthesist · 2018Article
- A Dual Role for Hyperbaric Oxygen in Stroke Neuroprotection: Preconditioning of the Brain and Stem Cells.Conditioning medicine · 2018Article
- Normobaric hyperoxia inhibits the progression of lung cancer by inducing apoptosis.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Proteomic analysis of mitochondrial proteins in the guinea pig heart following long-term normobaric hyperoxia.Molecular and cellular biochemistry · 2017Article
- Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury.Science advances · 2017Article
- Co-administration of tissue plasminogen activator and hyperbaric oxygen in ischemic stroke: a continued promise for neuroprotection.Medical gas researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials. In this article, we review the current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies and try to analyze and identify the key gaps or unknowns in our understanding about NBO. Based on these analyses, we provide suggestions for future studies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.