Evidence map›Paper›PMID 27867434›Full record

ArticleThe open neuroimaging journal2016

Exploring the Neurocircuitry Underpinning Predictability of Threat in Soldiers with PTSD Compared to Deployment Exposed Controls.

Michael N Dretsch, Kimberly H Wood, Thomas A Daniel, Jeffrey S Katz, Gopikrishna Deshpande, Adam M Goodman, Muriah D Wheelock, Kayli B Wood, Thomas S Denney, Stephanie Traynham and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The open neuroimaging journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response.Progress in neuro-psychopharmacology & biological psychiatry · 2019
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Frontal Lobe Circuitry in Posttraumatic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael N DretschU.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, USA; Human Dimension Division, HQ TRADOC, 950 Jefferson Ave, Fort Eustis, VA 23604, USA.
Kimberly H WoodDepartment of Psychology, University of Alabama at Birmingham, AL, USA.
Thomas A DanielDepartment of Psychology, Auburn University, Auburn, AL, USA; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Jeffrey S KatzDepartment of Psychology, Auburn University, Auburn, AL, USA; AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA.
Gopikrishna DeshpandeDepartment of Psychology, Auburn University, Auburn, AL, USA; AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA.
Adam M GoodmanDepartment of Psychology, Auburn University, Auburn, AL, USA; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Muriah D WheelockDepartment of Psychology, University of Alabama at Birmingham, AL, USA.
Kayli B WoodDepartment of Psychology, University of Alabama at Birmingham, AL, USA.
Thomas S DenneyDepartment of Psychology, Auburn University, Auburn, AL, USA; AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA.
Stephanie TraynhamU.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, USA.
David C KnightDepartment of Psychology, University of Alabama at Birmingham, AL, USA.

Funding

Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

backgroundPrior work examining emotional dysregulation observed in posttraumatic stress disorder (PTSD) has primarily been limited to fear-learning processes specific to anticipation, habituation, and extinction of threat. In contrast, the response to threat itself has not been systematically evaluated.

objectiveTo explore potential disruption in fear conditioning neurocircuitry in service members with PTSD, specifically in response to predictable

methodIn the current study, active-duty U.S. Army soldiers with (PTSD group;

resultsBoth groups showed greater threat expectancy and diminished threat-elicited SCRs to predictable compared to unpredictable threat. Significant group differences were observed within the amygdala, hippocampus, insula, and superior and middle temporal gyri. Contrary to our predictions, the PTSD group showed a diminished threat-related response within each of these brain regions during predictable compared to unpredictable threat, whereas the DEC group showed increased activation.

conclusionAlthough, the PTSD group showed greater threat-related diminution, hypersensitivity to unpredictable threat cannot be ruled out. Furthermore, pre-trauma, trait-like factors may have contributed to group differences in activation of the neurocircuitry underpinning fear conditioning.

Indexed as

AmygdalaFear-conditioningHippocampusInsulaMilitaryNeuroimagingPTSD

Identifiers

PMID27867434
PMCPMC5101630

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.