Evidence map›Paper›PMID 27867379›Full record

ReviewFrontiers in immunology2016

Convergence of Innate and Adaptive Immunity during Human Aging.

Branca I Pereira, Arne N Akbar

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  14. CD56 on immune and tumor cells: what is known and beyond?Clinical and experimental immunology · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Branca I PereiraDivision of Infection and Immunity, University College London , London , UK.
Arne N AkbarDivision of Infection and Immunity, University College London , London , UK.
University College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E019188/1Biotechnology and Biological Sciences Research Council BB/H020519/1Biotechnology and Biological Sciences Research Council BB/J006750/1Medical Research Council MR/M003833/1Medical Research Council MR/N017749/1Medical Research Council MR/P00184X/1
6 · The paper itself

Abstract

Aging is associated with profound changes in the human immune system, a phenomenon referred to as immunosenescence. This complex immune remodeling affects the adaptive immune system and the CD8

Indexed as

agingimmunosenescenceinnate-like T lymphocytesnatural killer receptorsT cell receptor

Identifiers

PMID27867379
PMCPMC5095488
OpenAlexW2547522319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.