Evidence map›Paper›PMID 27867358›Full record

ArticleFrontiers in pharmacology2016

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex.

Rebeca Diez-Alarcia, Inés Ibarra-Lecue, Ángela P Lopez-Cardona, Javier Meana, Alfonso Gutierrez-Adán, Luis F Callado, Ekaitz Agirregoitia, Leyre Urigüen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 71 citations in OpenAlex.

  1. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review
  2. Article
  3. Article
  4. Cannabinoid Receptor Signaling is Dependent on Sub-Cellular Location.bioRxiv : the preprint server for biology · 2024
    Article
  5. Cannabinoid Tolerance in S426A/S430A xThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Role of CBAmerican journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  10. Article
  11. Article
  12. Identification of BiP as a CBThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  13. Article
  14. Article
  15. Neurobiology of cannabinoid receptor signaling
.Dialogues in clinical neuroscience · 2020
    Review
  16. Differential hepatoprotective role of the cannabinoid CBBritish journal of pharmacology · 2020
    Article
  17. Review
  18. Review
  19. Review
  20. Therapeutic targeting of HER2-CBProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rebeca Diez-AlarciaDepartment of Pharmacology, University of the Basque Country UPV/EHULeioa, Spain; Centro de Investigación Biomédica en Red de Salud MentalMadrid, Spain.
Inés Ibarra-LecueDepartment of Pharmacology, University of the Basque Country UPV/EHU Leioa, Spain.
Ángela P Lopez-CardonaDepartment of Animal Reproduction, Instituto Nacional de Tecnología Agraria y AlimentariaMadrid, Spain; G.I. Biogénesis, Universidad de AntioquiaAntioquia, Colombia.
Javier MeanaDepartment of Pharmacology, University of the Basque Country UPV/EHULeioa, Spain; Centro de Investigación Biomédica en Red de Salud MentalMadrid, Spain.
Alfonso Gutierrez-AdánDepartment of Animal Reproduction, Instituto Nacional de Tecnología Agraria y Alimentaria Madrid, Spain.
Luis F CalladoDepartment of Pharmacology, University of the Basque Country UPV/EHULeioa, Spain; Centro de Investigación Biomédica en Red de Salud MentalMadrid, Spain.
Ekaitz AgirregoitiaDepartment of Physiology, University of the Basque Country Leioa, Spain.
Leyre UrigüenDepartment of Pharmacology, University of the Basque Country UPV/EHULeioa, Spain; Centro de Investigación Biomédica en Red de Salud MentalMadrid, Spain.
Centro de Investigación Biomédica en Red de Salud Mental · ESUniversity of the Basque Country · ESInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESUniversidad de Antioquia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabinoid receptors are able to couple to different families of G proteins when activated by an agonist drug. It has been suggested that different intracellular responses may be activated depending on the ligand. The goal of the present study was to characterize the pattern of G protein subunit stimulation triggered by three different cannabinoid ligands, Δ

Indexed as

brainCB1 receptorCB2 receptorfunctional selectivityG proteinsscintillation proximity assay (SPA)

Identifiers

PMID27867358
PMCPMC5095132
OpenAlexW2547817106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.