Evidence map›Paper›PMID 27867326›Full record

ArticleCEUR workshop proceedings2013

Towards a Consistent and Scientifically Accurate Drug Ontology.

William R Hogan, Josh Hanna, Eric Joseph, Mathias Brochhausen

Abstract read
In one paragraph

Article in CEUR workshop proceedings, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. DDIEM: drug database for inborn errors of metabolism.Orphanet journal of rare diseases · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Development of a cardiac-centered frailty ontology.Journal of biomedical semantics · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Standardizing adverse drug event reporting data.Journal of biomedical semantics · 2014
    Article
  14. Design and evaluation of a bacterial clinical infectious diseases ontology.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William R HoganDivision of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Josh HannaDivision of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Eric JosephDivision of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Mathias BrochhausenDivision of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029884 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI LOWERY, CURTIS L · 2009 to 2011
$11.4M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Apollo: Increasing Access and Use of Epidemic Models Through the Development andR01GM101151 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOGAN, WILLIAM R, WAGNER, MICHAEL MATTHEW · 2012 to 2015
$2.2M
NCATS NIH HHS UL1 TR000039NCRR NIH HHS UL1 RR029884NIGMS NIH HHS R01 GM101151
6 · The paper itself

Abstract

Our use case for comparative effectiveness research requires an ontology of drugs that enables querying National Drug Codes (NDCs) by active ingredient, mechanism of action, physiological effect, and therapeutic class of the drug products they represent. We conducted an ontological analysis of drugs from the realist perspective, and evaluated existing drug terminology, ontology, and database artifacts from (1) the technical perspective, (2) the perspective of pharmacology and medical science (3) the perspective of description logic semantics (if they were available in Web Ontology Language or OWL), and (4) the perspective of our realism-based analysis of the domain. No existing resource was sufficient. Therefore, we built the Drug Ontology (DrOn) in OWL, which we populated with NDCs and other classes from RxNorm using only content created by the National Library of Medicine. We also built an application that uses DrOn to query for NDCs as outlined above, available at: http://ingarden.uams.edu/ingredients. The application uses an OWL-based description logic reasoner to execute end-user queries. DrOn is available at http://code.google.com/p/dr-on.

Identifiers

PMID27867326
PMCPMC5111807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.