Evidence map›Paper›PMID 27867202›Full record

SynthesisInternational journal of obesity (2005)2017

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.

S Yoneyama, J Yao, X Guo, L Fernandez-Rhodes, U Lim, J Boston, P Buzková, C S Carlson, I Cheng, B Cochran and 40 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  10. Diabetes · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors at 20 institutions in 2 countries.

S YoneyamaDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
J YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
X GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
L Fernandez-RhodesDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
U LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
J BostonCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA.
P BuzkováDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
C S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
I ChengCancer Prevention Institute of California, Fremont, CA, USA.
B CochranBaylor College of Medicine, Houston, TX, USA.
R CooperDepartment of Public Health Sciences, Loyola University, Chicago, IL, USA.
G EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M FornageThe Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
J GongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
M GrossMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
C C GuDepartment of Biostatistics, Washington University, St Louis, MO, USA.
J HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
C A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
B HendersonDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
L A HindorffDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
D HoustonDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
M R IrvinDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
R JacksonDepartment of Internal Medicine, Ohio State Medical Center, Columbus, OH, USA.
L KullerDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
M LeppertDepartment of Human Genetics, University of Utah, Salt Lake City, UT, USA.
C E LewisDepartment of Medicine, University of Alabama, Birmingham, AL, USA.
R LiDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
L Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
T C MatiseDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
K-Dh NguyenCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
A ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
N PankratzMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
L PoolerDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
M D RitchieDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, State College, PA, USA.
S A BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
C L WasselDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, VT, USA.
Y-D I ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
K D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
M AllisonDepartment of Preventive Medicine, School of Medicine, University of California San Diego, San Diego, CA, USA.
J I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
P J SchreinerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
F SchumacherDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
L WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
E BoerwinkleThe Human Genetics Center and Institute of Molecular Medicine, Houston, TX, USA.
C KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
U PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
S BuyskeDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
M GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
K E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Fred Hutch Cancer Center · USThe Lundquist Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · USJohns Hopkins University · USRutgers, The State University of New Jersey · USUniversity of Hawaiʻi at Mānoa · USNational Institutes of Health · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · USUniversity of Minnesota Medical Center · USCancer Prevention Institute of California · USCenter for Human Genetics · USLoyola University Chicago · USPennsylvania State University · USThe University of Texas Health Science Center at Houston · USUniversity of California San Diego · USUniversity of Geneva · CHUniversity of Pittsburgh · USUniversity of Utah · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
VALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
POPULATION STUDIEST32HD007168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 1985 to 2026
$13.8M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCI NIH HHS P01 CA033619NCI NIH HHS R01 CA129063NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NCI NIH HHS U01 CA164973NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR033176NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004801NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG004803NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007419NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01 WH032105NHLBI NIH HHS N01 WH032118NHLBI NIH HHS N01 WH042107NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL098077NHLBI NIH HHS T32 HL007055NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NICHD NIH HHS P2C HD050924NICHD NIH HHS T32 HD007168NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01 DK048443NIEHS NIH HHS P50 ES015915WHI NIH HHS N01 WH022110WHI NIH HHS N01 WH024152WHI NIH HHS N01 WH032100WHI NIH HHS N01 WH032108WHI NIH HHS N01 WH032111WHI NIH HHS N01 WH032115WHI NIH HHS N01 WH032119WHI NIH HHS N01 WH032122WHI NIH HHS N01 WH042129WHI NIH HHS N01 WH044221
6 · The paper itself

Abstract

BACKGROUND/

objectivesCentral adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of body mass index (BMI) and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations discovered among mainly European descendants are shared with African ancestry populations will help elucidate the biological underpinnings of abdominal fat deposition. SUBJECTS/

methodsTo identify the underlying functional genetic determinants of body fat distribution, we conducted an array-wide association meta-analysis among persons of African ancestry across seven studies/consortia participating in the Population Architecture using Genomics and Epidemiology (PAGE) consortium. We used the Metabochip array, designed for fine-mapping cardiovascular-associated loci, to explore novel array-wide associations with WC and WHR among 15 945 African descendants using all and sex-stratified groups. We further interrogated 17 known WHR regions for African ancestry-specific variants.

resultsOf the 17 WHR loci, eight single-nucleotide polymorphisms (SNPs) located in four loci were replicated in the sex-combined or sex-stratified meta-analyses. Two of these eight independently associated with WHR after conditioning on the known variant in European descendants (rs12096179 in TBX15-WARS2 and rs2059092 in ADAMTS9). In the fine-mapping assessment, the putative functional region was reduced across all four loci but to varying degrees (average 40% drop in number of putative SNPs and 20% drop in genomic region). Similar to previous studies, the significant SNPs in the female-stratified analysis were stronger than the significant SNPs from the sex-combined analysis. No novel associations were detected in the array-wide analyses.

conclusionsOf 17 previously identified loci, four loci replicated in the African ancestry populations of this study. Utilizing different linkage disequilibrium patterns observed between European and African ancestries, we narrowed the suggestive region containing causative variants for all four loci.

Indexed as

Genetic VariationAdiposityAdultBlack PeopleBody Fat DistributionFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleObesity, AbdominalPolymorphism, Single NucleotideWaist-Hip RatioWhite People

Identifiers

PMID27867202
PMCPMC5296276
OpenAlexW2550765870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.