ArticleThe Journal of reproduction and development2017
A unique mechanism regulating gene expression in 1-cell embryos.
Article in The Journal of reproduction and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- H3.1/3.2 regulate the initial progression of the gene expression program.Nucleic acids research · 2024Article
- Zygotic gene activation in mice: profile and regulation.The Journal of reproduction and development · 2022Review
- Functions and Regulation of Endogenous Retrovirus Elements during Zygotic Genome Activation: Implications for Improving Somatic Cell Nuclear Transfer Efficiency.Biomolecules · 2021Review
- Expression of Dux family genes in early preimplantation embryos.Scientific reports · 2020Article
- Function and Regulation of Histone H3 Lysine-4 Methylation During Oocyte Meiosis and Maternal-to-Zygotic Transition.Frontiers in cell and developmental biology · 2020Review
- Ubiquitin-proteasome system modulates zygotic genome activation in early mouse embryos and influences full-term development.The Journal of reproduction and development · 2018Article
- Regulation of zygotic gene activation by chromatin structure and epigenetic factors.The Journal of reproduction and development · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos.
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Registered trials
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