ArticleNeuroImage2018
Techniques for blood volume fMRI with VASO: From low-resolution mapping towards sub-millimeter layer-dependent applications.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 133 citations in OpenAlex.
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- Impact of thermal and physiological denoising on laminar functional connectivity.Scientific reports · 2026Article
- Human fMRI at 11.7T: Assessing feasibility, stability, and reliability on the Iseult scanner.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception.bioRxiv : the preprint server for biology · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Reduced physiology-induced temporal instability achieved with variable-flip-angle fast low-angle excitation echo-planar technique with multishot echo planar time-resolved imaging.Magnetic resonance in medicine · 2025Article
- Blood nulling versus tissue suppression: Enhancing integrated VASO and perfusion (VAPER) contrast for laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dynamic layer-specific processing in the prefrontal cortex during working memory.Communications biology · 2024Article
- Precision fMRI and cluster-failure in the individual brain.Human brain mapping · 2024Article
- Motion compensated structured low-rank reconstruction for 3D multi-shot EPI.Magnetic resonance in medicine · 2024Article
- A comparative analysis of the sensitivity and BOLD contamination of the VASO response at 3 Tesla: ME-DEPICTING vs. ME-EPI readouts.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Combining the benefits of 3D acquisitions and spiral readouts for VASO fMRI at UHF.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Unlocking near-whole-brain, layer-specific functional connectivity with 3D VAPER fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Next-generation MRI scanner designed for ultra-high-resolution human brain imaging at 7 Tesla.Nature methods · 2023Article
- Acquisition and processing methods of whole-brain layer-fMRI VASO and BOLD: The Kenshu dataset.Aperture neuro · 2023Article
- Article
- Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Quantitative cerebral blood volume (CBV) fMRI has the potential to overcome several specific limitations of BOLD fMRI. It provides direct physiological interpretability and promises superior localization specificity in applications of sub-millimeter resolution fMRI applications at ultra-high magnetic fields (7T and higher). Non-invasive CBV fMRI using VASO (vascular space occupancy), however, is inherently limited with respect to its data acquisition efficiency, restricting its imaging coverage and achievable spatial and temporal resolution. This limitation may be reduced with recent advanced acceleration and reconstruction strategies that allow two-dimensional acceleration, such as in simultaneous multi-slice (SMS) 2D-EPI or 3D-EPI in combination with CAIPIRINHA field-of-view shifting. In this study, we sought to determine the functional sensitivity and specificity of these readout strategies with VASO over a broad range of spatial resolutions; spanning from low spatial resolution (3mm) whole-cortex to sub-millimeter (0.75mm) slab-of-cortex (for cortical layer-dependent applications). In the thermal-noise-dominated regime of sub-millimeter resolutions, 3D-EPI-VASO provides higher temporal stability and sensitivity to detect changes in CBV compared to 2D-EPI-VASO. In this regime, 3D-EPI-VASO unveils task activation located in the cortical laminae with little contamination from surface veins, in contrast to the cortical surface weighting of GE-BOLD fMRI. In the physiological-noise-dominated regime of lower resolutions, however, 2D-SMS-VASO shows superior performance compared to 3D-EPI-VASO. Due to its superior sensitivity at a layer-dependent level, 3D-EPI VASO promises to play an important role in future neuroscientific applications of layer-dependent fMRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.