ArticleNeurobiology of learning and memory2017
Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit.
Article in Neurobiology of learning and memory, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity.Molecular psychiatry · 2026Article
- Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward.Biology of sex differences · 2025Article
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
- Adolescent alcohol disrupts development of noradrenergic neurons in the nucleus of the tractus solitarius and enhances stress behaviors in adulthood in mice in a sex specific manner.Addiction neuroscience · 2023Article
- Hippocampal fear engrams modulate ethanol-induced maladaptive contextual generalization in mice.Hippocampus · 2022Article
- Reciprocal midbrain-extended amygdala circuit activity in preclinical models of alcohol use and misuse.Neuropharmacology · 2022Review
- The role of the bed nucleus of the stria terminalis in the motivational control of instrumental action.Frontiers in behavioral neuroscience · 2022Article
- Binge ethanol drinking associated with sex-dependent plasticity of neurons in the insula that project to the bed nucleus of the stria terminalis.Neuropharmacology · 2021Article
- Extended Amygdala Neuropeptide Circuitry of Emotional Arousal: Waking Up on the Wrong Side of the Bed Nuclei of Stria Terminalis.Frontiers in behavioral neuroscience · 2021Article
- Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice.Hippocampus · 2021Article
- Effects of pharmacological inhibition of the centrally-projecting Edinger-Westphal nucleus on ethanol-induced conditioned place preference and body temperature.Alcohol (Fayetteville, N.Y.) · 2020Article
- Methods for mechanical delivery of viral vectors into rhesus monkey brain.Journal of neuroscience methods · 2020Article
- The BNST balances alcohol's aversive and rewarding properties.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The use of chemogenetic approaches in alcohol use disorder research and treatment.Alcohol (Fayetteville, N.Y.) · 2019Review
- Review
- The bed nucleus of the stria terminalis in drug-associated behavior and affect: A circuit-based perspective.Neuropharmacology · 2017Review
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2 authors at 1 institution in 1 country.
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Abstract
Abstinent alcohol-dependent individuals experience an enduring sensitivity to cue-induced craving and relapse to drinking. There is considerable evidence indicating that structures within the midbrain and extended amygdala are involved in this process. Individually, the ventral tegmental area (VTA) and the bed nucleus of the stria terminalis (BNST) have been shown to modulate cue-induced ethanol-seeking behavior. It is hypothesized that cue-induced seeking is communicated through a direct projection from the BNST to VTA. In the current experiments, an intersectional viral strategy was used in DBA/2J mice to selectively target and inhibit BNST projections to the VTA during a test of ethanol conditioned place preference (CPP). Inhibitory designer receptors exclusively activated by designer drugs (hM4Di DREADDs) were expressed in VTA-projecting BNST (BNST-VTA) cells by infusing a retrograde herpes-simplex virus encoding cre recombinase (HSV-Cre) into VTA and a cre-inducible adeno-associated virus encoding hM4Di (AAV-DIO-hM4Di) into BNST. Before testing the expression of preference, clozapine-N-oxide (CNO) was peripherally administered to activate hM4Di receptors and selectively inhibit these cells. Ethanol CPP expression was blocked by CNO-mediated inhibition of BNST-VTA cells. A follow-up study revealed this effect was specific to CNO activation of hM4Di as saline- and CNO-treated mice infused with a control vector (HSV-GFP) in place of HSV-Cre showed significant CPP. These findings establish a role for a direct BNST input to VTA in cue-induced ethanol-seeking behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.