ArticleNeuron2016
Inhibitory Control in the Cortico-Basal Ganglia-Thalamocortical Loop: Complex Regulation and Interplay with Memory and Decision Processes.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for a joint neural mechanism underlying response inhibition and state anger.Human brain mapping · 2020Pooled it
- A computational architecture incorporating shallow brain networks: integrating parallel cortical and subcortical processing.Current research in neurobiology · 2026Article
- Role of the primate ventral striatum as a neural hub bridging option valuation and action selection.Nature communications · 2026Article
- How the dynamic interplay of cortico-basal ganglia-thalamic pathways shapes the time course of deliberation and commitment.PLoS computational biology · 2026Article
- Decoupling of motor cortex to movement in Parkinson's dyskinesia rescued by sub-anaesthetic ketamine.Brain : a journal of neurology · 2025Article
- Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders.Neuropsychopharmacology reports · 2025Article
- Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts.Brain imaging and behavior · 2024Article
- Dorsal Anterior Cingulate Cortex Coordinates Contextual Mental Imagery for Single-Beat Manipulation during Rhythmic Sensorimotor Synchronization.Brain sciences · 2024Article
- Predicting suicidality in late-life depression by 3D convolutional neural network and cross-sample entropy analysis of resting-state fMRI.Brain and behavior · 2024Article
- Modeling saccade reaction time in marmosets: the contribution of earlier visual response and variable inhibition.Frontiers in systems neuroscience · 2024Article
- Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.Molecular psychiatry · 2023Article
- Neural mechanisms of domain-general inhibitory control.Trends in cognitive sciences · 2023Review
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.eLife · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.bioRxiv : the preprint server for biology · 2023Article
- Article
- Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.European archives of psychiatry and clinical neuroscience · 2023Article
- The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit.Psychoradiology · 2023Article
- Thalamic functional connectivity and sensorimotor processing in neurodevelopmental disorders.Frontiers in neuroscience · 2023Article
- Two Types of Motor Inhibition after Action Errors in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Efficacy and Mechanism of Moxibustion Treatment on Mild Cognitive Impairment Patients: An fMRI Study Using ALFF.Frontiers in molecular neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We developed a circuit model of spiking neurons that includes multiple pathways in the basal ganglia (BG) and is endowed with feedback mechanisms at three levels: cortical microcircuit, corticothalamic loop, and cortico-BG-thalamocortical system. We focused on executive control in a stop signal task, which is known to depend on BG across species. The model reproduces a range of experimental observations and shows that the newly discovered feedback projection from external globus pallidus to striatum is crucial for inhibitory control. Moreover, stopping process is enhanced by the cortico-subcortical reverberatory dynamics underlying persistent activity, establishing interdependence between working memory and inhibitory control. Surprisingly, the stop signal reaction time (SSRT) can be adjusted by weights of certain connections but is insensitive to other connections in this complex circuit, suggesting novel circuit-based intervention for inhibitory control deficits associated with mental illness. Our model provides a unified framework for inhibitory control, decision making, and working memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.