Evidence map›Paper›PMID 27866770›Full record

ArticleVaccine2016

Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence.

Vimala Devi Janjanam, Nandini Mukherjee, Gabrielle A Lockett, Faisal I Rezwan, Ramesh Kurukulaaratchy, Frances Mitchell, Hongmei Zhang, Hasan Arshad, John W Holloway, Wilfried Karmaus

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Vimala Devi JanjanamDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, 236A Robison Hall, Memphis, TN 38152, USA. Electronic address: vjnjanam@memphis.edu.
Nandini MukherjeeDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, 236A Robison Hall, Memphis, TN 38152, USA. Electronic address: nmkhrjee@memphis.edu.
Gabrielle A LockettHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK. Electronic address: g.a.lockett@soton.ac.uk.
Faisal I RezwanClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK. Electronic address: F.Rezwan@soton.ac.uk.
Ramesh KurukulaaratchyThe David Hide Asthma and Allergy Research Centre, St Mary's, Hospital, Parkhurst Road, Newport, Isle of Wight PO30 5TG, UK; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton SO16 6YD, UK. Electronic address: rjk1s07@soton.ac.uk.
Frances MitchellThe David Hide Asthma and Allergy Research Centre, St Mary's, Hospital, Parkhurst Road, Newport, Isle of Wight PO30 5TG, UK. Electronic address: Frances.Mitchell@iow.nhs.uk.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, 236A Robison Hall, Memphis, TN 38152, USA. Electronic address: hzhang6@memphis.edu.
Hasan ArshadThe David Hide Asthma and Allergy Research Centre, St Mary's, Hospital, Parkhurst Road, Newport, Isle of Wight PO30 5TG, UK; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton SO16 6YD, UK. Electronic address: s.h.arshad@soton.ac.uk.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK. Electronic address: J.W.Holloway@soton.ac.uk.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, 236A Robison Hall, Memphis, TN 38152, USA. Electronic address: karmaus1@memphis.edu.
University of Memphis · USUniversity of Southampton · GBDavid Hide Asthma and Allergy Research Centre · GBSt Mary's Hospital · GB

Funding

Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
Medical Research CouncilNIAID NIH HHS R01 AI091905NIAID NIH HHS R01 AI121226Wellcome Trust
6 · The paper itself

Abstract

backgroundVaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with increased serum IgE levels. We hypothesized that the vaccination modifies the risk of allergic diseases through epigenetic changes such as DNA methylation.

methodData on tetanus vaccination between 10 and 18years of age was collected from a birth cohort established on the Isle of Wight UK in 1989. DNA methylation data were collected from individuals at different ages (at birth [n=30], age 10 [n=34], age 18 [n=245] and during pregnancy [n=121]) using the Illumina Infinium HumanMethylation450K array. Firstly, we performed an epigenome-wide screening to identify cytosine-phosphate-guanine sites (CpGs) associated with tetanus vaccination in 18-year-olds. Secondly, we tested their association with asthma, allergic sensitization, eczema, serum IgE and pulmonary lung function (FVC, FEV1, FEV1/FVC, and FEF25-75%). We then described changes in the methylation of the selected CpG sites over age, and by vaccination status.

resultsTetanus vaccination was found to be associated with decreased methylation of cg14472551 (p value 0.5×10

conclusionDNA methylation changes following tetanus vaccination may offer a novel prospect to explain a differential occurrence of asthma in adolescence.

Indexed as

DNA MethylationEpigenesis, GeneticAdolescentAdultAsthmaChildChild, PreschoolCohort StudiesFemaleHumansInfantMalePregnancyRisk AssessmentSurveys and QuestionnairesTetanus ToxoidTetanus ToxoidAsthmaDNA-methylationEpigeneticsTetanusVaccination

Identifiers

PMID27866770
PMCPMC5131880
OpenAlexW2554529407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.