ArticleJournal of biomechanics2017
Patient-specific CFD models for intraventricular flow analysis from 3D ultrasound imaging: Comparison of three clinical cases.
Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Experimental and computational models for intracardiac flow analysis with blood speckle imaging.PloS one · 2026Article
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- Image-Based Computational Fluid Dynamics to Compare Two Repair Techniques for Mitral Valve Prolapse.Annals of biomedical engineering · 2024Article
- Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI.Biomechanics and modeling in mechanobiology · 2023Article
- 4D Flow Patterns and Relative Pressure Distribution in a Left Ventricle Model by Shake-the-Box and Proper Orthogonal Decomposition Analysis.Cardiovascular engineering and technology · 2023Article
- An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse.Cardiovascular engineering and technology · 2023Article
- Significance of aortoseptal angle anomalies to left ventricular hemodynamics and subaortic stenosis: A numerical study.Computers in biology and medicine · 2022Article
- Intraventricular Flow Simulations in Singular Right Ventricles Reveal Deteriorated Washout and Low Vortex Formation.Cardiovascular engineering and technology · 2022Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- A CFD study on the interplay of torsion and vortex guidance by the mitral valve on the left ventricular wash-out making use of overset meshes (Chimera technique).Frontiers in medical technology · 2022Article
- Computational investigation of left ventricular hemodynamics following bioprosthetic aortic and mitral valve replacement.Mechanics research communications · 2021Article
- In Vivo Image-Based 4D Modeling of Competent and Regurgitant Mitral Valve Dynamics.Experimental mechanics · 2021Article
- Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy.Frontiers in physiology · 2021Article
- Combining statistical shape modeling, CFD, and meta-modeling to approximate the patient-specific pressure-drop across the aortic valve in real-time.International journal for numerical methods in biomedical engineering · 2020Article
- Finite Element Driven Design Domain Identification of a Beating Left Ventricular Simulator.Bioengineering (Basel, Switzerland) · 2019Article
- Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities.Frontiers in physiology · 2018Review
- Fully-coupled fluid-structure interaction simulation of the aortic and mitral valves in a realistic 3D left ventricle model.PloS one · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAs the intracardiac flow field is affected by changes in shape and motility of the heart, intraventricular flow features can provide diagnostic indications. Ventricular flow patterns differ depending on the cardiac condition and the exploration of different clinical cases can provide insights into how flow fields alter in different pathologies.
methodsIn this study, we applied a patient-specific computational fluid dynamics model of the left ventricle and mitral valve, with prescribed moving boundaries based on transesophageal ultrasound images for three cardiac pathologies, to verify the abnormal flow patterns in impaired hearts. One case (P1) had normal ejection fraction but low stroke volume and cardiac output, P2 showed low stroke volume and reduced ejection fraction, P3 had a dilated ventricle and reduced ejection fraction.
resultsThe shape of the ventricle and mitral valve, together with the pathology influence the flow field in the left ventricle, leading to distinct flow features. Of particular interest is the pattern of the vortex formation and evolution, influenced by the valvular orifice and the ventricular shape. The base-to-apex pressure difference of maximum 2mmHg is consistent with reported data.
conclusionWe used a CFD model with prescribed boundary motion to describe the intraventricular flow field in three patients with impaired diastolic function. The calculated intraventricular flow dynamics are consistent with the diagnostic patient records and highlight the differences between the different cases. The integration of clinical images and computational techniques, therefore, allows for a deeper investigation intraventricular hemodynamics in patho-physiology.
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