Evidence map›Paper›PMID 27866512›Full record

ArticleBMB reports2016

Age-related epigenetic regulation in the brain and its role in neuronal diseases.

Jeongsil Kim-Ha, Young-Joon Kim

Abstract readNews
In one paragraph

Article in BMB reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Biomarkers of aging.Science China. Life sciences · 2023
    Review
  6. Article
  7. Pathways of Non-enzymatic Lysine Acylation.Frontiers in cell and developmental biology · 2021
    Review
  8. Review
  9. Review
  10. Alteration of the brain methylation landscape following postnatal inflammatory injury in rat pups.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  11. Review
  12. Genomics: New Light on Alzheimer's Disease Research.International journal of molecular sciences · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeongsil Kim-HaDepartment of Integrative Bioscience and Biotechnology, College of Life Sciences, Sejong University, Seoul 05006, Korea.
Young-Joon KimDepartment of Integrated Omics for Biomedical Science, Graduate School, Yonsei University, and Department of Biochemistry, College of Life Science and Technology, Yonsei University, Seoul 03722, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence indicates many brain functions are mediated by epigenetic regulation of neural genes, and their dysregulations result in neuronal disorders. Experiences such as learning and recall, as well as physical exercise, induce neuronal activation through epigenetic modifications and by changing the noncoding RNA profiles. Animal models, brain samples from patients, and the development of diverse analytical methods have broadened our understanding of epigenetic regulation in the brain. Diverse and specific epigenetic changes are suggested to correlate with neuronal development, learning and memory, aging and age-related neuronal diseases. Although the results show some discrepancies, a careful comparison of the data (including methods, regions and conditions examined) would clarify the problems confronted in understanding epigenetic regulation in the brain. [BMB Reports 2016; 49(12): 671-680].

Indexed as

AgingEpigenesis, GeneticAlzheimer DiseaseAnimalsBrainDNA MethylationHistone Deacetylase InhibitorsHistonesHumansHuntington DiseaseNeurodegenerative DiseasesParkinson DiseaseHistone Deacetylase InhibitorsHistones

Identifiers

PMID27866512
PMCPMC5346312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.