Evidence map›Paper›PMID 27866510›Full record

ArticleEpidemiology and psychiatric sciences2018

Cancer incidence in young and middle-aged people with schizophrenia: nationwide cohort study in Taiwan, 2000-2010.

L Y Chen, Y N Hung, Y Y Chen, S Y Yang, C H Pan, C C Chen, C J Kuo

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Article in Epidemiology and psychiatric sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

L Y ChenTaipei City Psychiatric Center,Songde Branch,Taipei City Hospital,Taipei,Taiwan.
Y N HungSchool of Gerontology Health Management and Master Program in Long-Term Care,College of Nursing,Taipei Medical University,Tainan,Taiwan.
Y Y ChenTaipei City Psychiatric Center,Songde Branch,Taipei City Hospital,Taipei,Taiwan.
S Y YangTaipei City Psychiatric Center,Songde Branch,Taipei City Hospital,Taipei,Taiwan.
C H PanTaipei City Psychiatric Center,Songde Branch,Taipei City Hospital,Taipei,Taiwan.
C C ChenDepartment of Psychiatry,School of Medicine,Taipei Medical University and Psychiatric Research Center,Taipei Medical University Hospital,Taipei,Taiwan.
C J KuoTaipei City Psychiatric Center,Songde Branch,Taipei City Hospital,Taipei,Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsFor nearly a century, the incidence of cancer in people with schizophrenia was lower than in the general population. In the recent decade, the relationship between cancer and schizophrenia has become obscured. Thus, we investigated the cancer risk among young and middle-aged patients with schizophrenia.

methodsRecords of newly admitted patients with schizophrenia (n = 32 731) from January 2000 through December 2008 were retrieved from the Psychiatric Inpatient Medical Claims database in Taiwan, and the first psychiatric admission of each patient during the same period was defined as the baseline. We obtained 514 incident cancer cases that were monitored until December 2010. Standardised incidence ratios (SIRs) were calculated to compare the risk of cancer between those with schizophrenia and the general population. Stratified analyses of cancer incidences were performed by gender, site of cancers and duration since baseline (first psychiatric admission).

resultsThe incidence of cancer for all sites was slightly higher than that of the general population for the period (SIR = 1.15 [95% CI 1.06-1.26], p = 0.001). Men had a significantly higher incidence of colorectal cancer (SIR = 1.48 [95% CI 1.06-2.06], p = 0.019). Women had a higher incidence of breast cancer (SIR = 1.47 [95% CI 1.22-1.78], p < 0.001). Intriguingly, the risk for colorectal cancer was more pronounced 5 years after the first psychiatric admission rather than earlier (SIR = 1.94 [1.36-2.75], p < 0.001) and so was the risk for breast cancer (SIR = 1.85 [1.38-2.48], p < 0.001). The cancer incidence was higher in patients with schizophrenia contradicting the belief that schizophrenia was protective of cancers.

conclusionsOur analyses suggest that men and women with schizophrenia were more vulnerable to certain types of cancers, which indicates the need for gender-specific cancer screening programs. The fact that risk of colorectal cancer was more pronounced 5 years after the first psychiatric admission could imply the impact of unhealthy lifestyles or the possibility of delayed diagnoses.

Indexed as

AdolescentAdultAge DistributionBreast NeoplasmsCohort StudiesColorectal NeoplasmsDatabases, FactualFemaleHumansIncidenceMaleMiddle AgedNeoplasmsRisk FactorsSchizophreniaSex DistributionBreast cancercancercolorectal cancerschizophreniastandardised incidence ratio (SIR)

Identifiers

PMID27866510
PMCPMC6998952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.