Evidence map›Paper›PMID 27866487›Full record

ArticleEpidemiology and infection2017

Tuberculosis infection testing in HIV-positive men who have sex with men from Xi'an China.

H N Xin, X W Li, L Zhang, Z Li, H R Zhang, Y Yang, M F Li, B X Feng, H J Li, L Gao

Abstract read
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

H N XinMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
X W LiMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
L ZhangBeijing Center for Disease Prevention and Control,Beijing,China.
Z LiMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
H R ZhangMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
Y YangDepartment of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Centre,Beijing,China.
M F LiMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
B X FengMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
H J LiMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.
L GaoMOH Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In individuals with latent tuberculosis (TB) infection, those living with human immunodeficiency virus (HIV) had a 20-37 times higher risk of developing active TB compared to those without HIV infection. Systematic testing and treatment of latent TB infection are priorities in HIV-infected persons. In China, the prevalence of HIV infection in men who have sex with men (MSM) has gradually increased in the past decade. However, the prevalence of TB infection has been studied sparsely in HIV-infected MSM. Hence, we conducted a pilot study in MSM living with HIV infection in Xi'an city to evaluate TB infection status by means of interferon-γ release assay (IGRA). A total of 182 HIV-infected MSM were included in this study, the prevalence of IGRA positivity was observed to be 8·79% (16/182). IGRA quantitative results were not statistically influenced by the CD4 cell counts of the study participants. However, IGRA positivity was found to be lower than our previously reported data from the general population. This suggests that immunological deficiency might decrease the sensitivity of IGRA and thus increase the number of false negatives. Our primary results, suggesting systematic testing and treatment of latent TB infection together with active case-finding, were equally important for TB control in persons living with HIV infection.

Indexed as

Sexual and Gender MinoritiesAdolescentAdultChinaHIV InfectionsHumansInterferon-gamma Release TestsMaleMiddle AgedPilot ProjectsPrevalenceTuberculosisYoung AdultHIVinterferon-γ release assaymen who have sex with menTB infection

Identifiers

PMID27866487
PMCPMC9507714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.