SynthesisActa neuropsychiatrica2018
The effects of cannabis use on salience attribution: a systematic review.
Synthesis in Acta neuropsychiatrica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- The relationship between recreational cannabis use, psychotic-like experiences, and the salience network in adolescent and young adult twins.Psychological medicine · 2025Article
- Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors.Psychological medicine · 2025Article
- Overshadowing and salience attribution in relation to cannabis use.Schizophrenia research. Cognition · 2024Article
- Impact of prenatal cannabis exposure on functional connectivity of the salience network in children.Journal of neuroscience research · 2023Article
- Aberrant salience in cannabis-induced psychosis: a comparative study.Frontiers in psychiatry · 2023Article
- Latent inhibition, aberrant salience, and schizotypy traits in cannabis users.Schizophrenia research. Cognition · 2022Article
- Cannabinoids, reward processing, and psychosis.Psychopharmacology · 2022Review
- Understanding the genetics and neurobiological pathways behind addiction (Review).Experimental and therapeutic medicine · 2021Review
- Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats.International journal of molecular sciences · 2021Article
- Cannabis Use, Schizotypy and Kamin Blocking Performance.Frontiers in psychiatry · 2021Article
- Alterations in Rat Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Role of Ghrelin.International journal of molecular sciences · 2020Article
- Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations.Psychopharmacology · 2020Article
- Is the Adolescent Brain at Greater Vulnerability to the Effects of Cannabis? A Narrative Review of the Evidence.Frontiers in psychiatry · 2020Review
- Brain activation to cannabis- and alcohol-related words in alcohol use disorder.Psychiatry research. Neuroimaging · 2019Article
- Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Cannabis Addiction and the Brain: a Review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveThe relationship between cannabis use and the onset of psychosis is well established. Aberrant salience processing is widely thought to underpin many of these symptoms. Literature explicitly investigating the relationship between aberrant salience processing and cannabis use is scarce; with those few studies finding that acute tetrahydrocannabinol (THC) administration (the main psychoactive component of cannabis) can result in abnormal salience processing in healthy cohorts, mirroring that observed in psychosis. Nevertheless, the extent of and mechanisms through which cannabis has a modulatory effect on aberrant salience, following both acute and chronic use, remain unclear.
methodsHere, we systematically review recent findings on the effects of cannabis use - either through acute THC administration or in chronic users - on brain regions associated with salience processing (through functional MRI data); and performance in cognitive tasks that could be used as either direct or indirect measures of salience processing. We identified 13 studies either directly or indirectly exploring salience processing. Three types of salience were identified and discussed - incentive/motivational, emotional/affective, and attentional salience.
resultsThe results demonstrated an impairment of immediate salience processing, following acute THC administration. Amongst the long-term cannabis users, normal salience performance appeared to be underpinned by abnormal neural processes.
conclusionsOverall, the lack of research specifically exploring the effects of cannabis use on salience processing, weaken any conclusions drawn. Additional research explicitly focussed on salience processing and cannabis use is required to advance our understanding of the neurocognitive mechanisms underlying the association between cannabis use and development of psychosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.