Evidence map›Paper›PMID 27866370›Full record

ArticleJournal of biomolecular NMR2016

Perspective: revisiting the field dependence of TROSY sensitivity.

Koh Takeuchi, Haribabu Arthanari, Gerhard Wagner

Abstract readLetter
In one paragraph

Article in Journal of biomolecular NMR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Chemical communications (Cambridge, England) · 2022
    Article
  2. Review
  3. Protein in-cell NMR spectroscopy at 1.2 GHz.Journal of biomolecular NMR · 2021
    Article
  4. Review
  5. More than Proton Detection-New Avenues for NMR Spectroscopy of RNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Review
  6. Review
  7. Article
  8. Article
  9. Robust and transferable quantification of NMR spectral quality using IROC analysis.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017
    Article
  10. Evaluation ofJournal of biomolecular NMR · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Koh TakeuchiMolecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Tokyo, 135-0064, Japan.
Haribabu ArthanariDepartment of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.
Gerhard WagnerDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. gerhard_wagner@hms.harvard.edu.ORCID 0000-0002-2063-4401

Funding

T CELL SPECIFIC TRANSCRIPTION COMPLEXESP01GM047467 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAGNER, GERHARD · 1992 to 2017
$28.6M
OverallP41EB002026 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2003 to 2018
$17.9M
NIBIB NIH HHS P41 EB002026NIGMS NIH HHS P01 GM047467
6 · The paper itself

Abstract

The discovery of the TROSY effect (Pervushin et al. in Proc Natl Acad Sci USA 94:12366-12371, 1997) for reducing transverse relaxation and line sharpening through selecting pathways in which dipole-dipole and CSA Hamiltonians partially cancel each other had a tremendous impact on solution NMR studies of macromolecules. Together with the methyl TROSY (Tugarinov and Kay in J Biomol NMR 28:165-172, 2004) it enabled structural and functional studies of significantly larger systems. The optimal field strengths for TROSY have been estimated to be on spectrometers operating around 900 MHz (21.14 T) for the

Indexed as

Magnetic Resonance Spectroscopy13C detection15N detectionAromatic TROSYCSAField dependenceSensitivityTROSY

Identifiers

PMID27866370
PMCPMC5218892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.