Evidence map›Paper›PMID 27866337›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

Mental and physical health correlates among family caregivers of patients with newly-diagnosed incurable cancer: a hierarchical linear regression analysis.

Kelly M Shaffer, Jamie M Jacobs, Ryan D Nipp, Alaina Carr, Vicki A Jackson, Elyse R Park, William F Pirl, Areej El-Jawahri, Emily R Gallagher, Joseph A Greer and 1 more

Abstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Observational
  7. Quality of life and burden in family caregivers of advanced cancer patients in the Grand Duchy of Luxembourg: results from a single-centre study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  11. Caregiver experiences managing information prior to hematopoietic stem cell transplantation and after transition to home: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  14. Multilevel barriers and supportive care preferences of metastatic breast cancer patients and their caregivers: a mixed-methods analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kelly M ShafferMassachusetts General Hospital, Boston, MA, USA.
Jamie M JacobsMassachusetts General Hospital, Boston, MA, USA.
Ryan D NippHarvard Medical School, Boston, MA, USA.
Alaina CarrDivision of Hematology/Oncology, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.
Vicki A JacksonHarvard Medical School, Boston, MA, USA.
Elyse R ParkMassachusetts General Hospital, Boston, MA, USA.
William F PirlHarvard Medical School, Boston, MA, USA.
Areej El-JawahriHarvard Medical School, Boston, MA, USA.
Emily R GallagherDivision of Hematology/Oncology, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Yawkey 7B, Boston, MA, 02114, USA.
Joseph A GreerHarvard Medical School, Boston, MA, USA.
Jennifer S TemelHarvard Medical School, Boston, MA, USA. jtemel@partners.org.
Massachusetts General Hospital · USHarvard University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Psychosocial Palliative & Community Research in CancerT32CA009461 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JENNIFER L HAY, Jamie S. Ostroff · 1985 to 2026
$10.1M
A Randomized trial of early palliative care for newly diagnosed cancer patientsR01NR012735 · NINR · MASSACHUSETTS GENERAL HOSPITAL · PI TEMEL, JENNIFER SUE · 2011 to 2015
$2.1M
Optimizing Palliative and End of Life Care for Patients with CancerK24CA181253 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TEMEL, JENNIFER SUE · 2014 to 2018
$737k
NCI NIH HHS K24 CA181253NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA009461NINR NIH HHS R01 NR012735
6 · The paper itself

Abstract

purposeCaregiver, relational, and patient factors have been associated with the health of family members and friends providing care to patients with early-stage cancer. Little research has examined whether findings extend to family caregivers of patients with incurable cancer, who experience unique and substantial caregiving burdens. We examined correlates of mental and physical health among caregivers of patients with newly-diagnosed incurable lung or non-colorectal gastrointestinal cancer.

methodsAt baseline for a trial of early palliative care, caregivers of participating patients (N = 275) reported their mental and physical health (Medical Outcome Survey-Short Form-36); patients reported their quality of life (Functional Assessment of Cancer Therapy-General). Analyses used hierarchical linear regression with two-tailed significance tests.

resultsCaregivers' mental health was worse than the U.S. national population (M = 44.31, p < .001), yet their physical health was better (M = 56.20, p < .001). Hierarchical regression analyses testing caregiver, relational, and patient factors simultaneously revealed that younger (B = 0.31, p = .001), spousal caregivers (B = -8.70, p = .003), who cared for patients reporting low emotional well-being (B = 0.51, p = .01) reported worse mental health; older (B = -0.17, p = .01) caregivers with low educational attainment (B = 4.36, p < .001) who cared for patients reporting low social well-being (B = 0.35, p = .05) reported worse physical health.

conclusionsIn this large sample of family caregivers of patients with incurable cancer, caregiver demographics, relational factors, and patient-specific factors were all related to caregiver mental health, while caregiver demographics were primarily associated with caregiver physical health. These findings help identify characteristics of family caregivers at highest risk of poor mental and physical health who may benefit from greater supportive care.

Indexed as

AdultAgedAged, 80 and overCaregiversFamilyFamily HealthFemaleGastrointestinal NeoplasmsHumansLinear ModelsLung NeoplasmsMaleMental HealthMiddle AgedPalliative CareQuality of LifeIncurable cancerInformal caregivingMental healthPalliative carePhysical health

Identifiers

PMID27866337
PMCPMC5269509
OpenAlexW2554590428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.