Evidence map›Paper›PMID 27866283›Full record

Trial reportEuropean child & adolescent psychiatry2017

Learning curves of theta/beta neurofeedback in children with ADHD.

Tieme W P Janssen, Marleen Bink, Wouter D Weeda, Katleen Geladé, Rosa van Mourik, Athanasios Maras, Jaap Oosterlaan

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in European child & adolescent psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01363544 (Train Your Brain? Exercise and Neurofeedback Intervention for ADHD), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01363544 phase2 / phase3completednot on this map

Train Your Brain? Exercise and Neurofeedback Intervention for ADHD

TypeinterventionalSponsorR. van MourikRan2010 to 2015Enrolled112ConditionsAttention Deficit Hyperactivity Disorder (ADHD)ArmsNeurofeedback, Exercise, methylphenidate
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

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  12. A Case Study in Attention-Deficit/Hyperactivity Disorder: An Innovative Neurofeedback-Based Approach.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Tieme W P JanssenClinical Neuropsychology Section, Vrije Universiteit, Van Der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands. twp.janssen@vu.nl.
Marleen BinkClinical Neuropsychology Section, Vrije Universiteit, Van Der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Wouter D WeedaDepartment of Psychology, Leiden University, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands.
Katleen GeladéClinical Neuropsychology Section, Vrije Universiteit, Van Der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Rosa van MourikRoyal Dutch Kentalis, Vlampijpstraat 78, 3534 AR, Utrecht, The Netherlands.
Athanasios MarasYulius Academy, Dennenhout 1, 2994 GC, Barendracht, The Netherlands.
Jaap OosterlaanClinical Neuropsychology Section, Vrije Universiteit, Van Der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Vrije Universiteit Amsterdam · NLLeiden University · NLRoyal Dutch Kentalis · NLYulius · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurofeedback is widely applied as non-pharmacological intervention aimed at reducing symptoms of ADHD, even though efficacy has not been unequivocally established. Neuronal changes during the neurofeedback intervention that resemble learning can provide crucial evidence for the feasibility and specificity of this intervention. A total of 38 children (aged between 7 and 13 years) with a DSM-IV-TR diagnosis of ADHD, completed on average 29 sessions of theta (4-8 Hz)/beta (13-20 Hz) neurofeedback training. Dependent variables included training-related measures as well as theta and beta power during baseline and training runs for each session. Learning effects were analyzed both within and between sessions. To further specify findings, individual learning curves were explored and correlated with behavioral changes in ADHD symptoms. Over the course of the training, there was a linear increase in participants' mean training level, highest obtained training level and the number of earned credits (range b = 0.059, -0.750, p < 0.001). Theta remained unchanged over the course of the training, while beta activity increased linearly within training sessions (b = 0.004, 95% CI = [0.0013-0.0067], p = 0.005) and over the course of the intervention (b = 0.0052, 95% CI = [0.0039-0.0065], p < 0.001). In contrast to the group analyses, significant individual learning curves were found for both theta and beta over the course of the intervention in 39 and 53%, respectively. Individual learning curves were not significantly correlated with behavioral changes. This study shows that children with ADHD can gain control over EEG states during neurofeedback, although a lack of behavioral correlates may indicate insufficient transfer to daily functioning, or to confounding reinforcement of electromyographic activity. CLINICAL TRIALS REGISTRATION: This trial is registered at the US National Institutes of Health (ClinicalTrials.gov, ref. no: NCT01363544); https://clinicaltrials.gov/show/NCT01363544 .

Indexed as

ExerciseLearning CurveAdolescentAttention Deficit Disorder with HyperactivityChildDiagnostic and Statistical Manual of Mental DisordersDopamine Uptake InhibitorsElectroencephalographyFemaleHumansMaleMethylphenidateNeurofeedbackOutcome and Process Assessment, Health CareDopamine Uptake InhibitorsMethylphenidateADHDEEGLearning curvesNeurofeedbackPaediatricTheta/beta-training

Identifiers

PMID27866283
PMCPMC5394134
OpenAlexW2555589390

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.