ArticlePflugers Archiv : European journal of physiology2017
Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy.
Article in Pflugers Archiv : European journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model.PLoS computational biology · 2023Article
- Expression and functional maintenance of volume-regulated anion channels in myometrial smooth muscles of pregnant mice.Experimental animals · 2022Article
- Modeling and experimental approaches for elucidating multi-scale uterine smooth muscle electro- and mechano-physiology: A review.Frontiers in physiology · 2022Review
- Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021Review
- Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ryanodine receptor type 3 (RyR3) is expressed in myometrial smooth muscle cells (MSMCs). The short isoform of RyR3 is a dominant negative variant (DN-RyR3) and negatively regulates the functions of RyR2 and full-length (FL)-RyR3. DN-RyR3 has been suggested to function as a major RyR3 isoform in non-pregnant (NP) mouse MSMCs, and FL-RyR3 may also be upregulated during pregnancy (P). This increase in the FL-RyR3/DN-RyR3 ratio may contribute to the strong contractions by MSMCs for parturition. In the present study, spontaneous contractions by the myometrium in NP and P mice were highly susceptible to nifedipine but were not affected by ryanodine. Ca
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