Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats.

Narongrit Thongon, Jirawat Penguy, Sasikan Kulwong, Kanyanat Khongmueang, Matthana Thongma

Abstract read

In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it

0cells of the map it votes in

15citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells.World journal of gastrointestinal oncology · 2025
Article
Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment.Pflugers Archiv : European journal of physiology · 2025
Article
Multiple electrolyte disorders triggered by proton pump inhibitor-induced hypomagnesemia: Case reports with a mini-review of the literature.Clinical nephrology. Case studies · 2024
Article
Bariatric Surgery and Inflammatory Bowel Disease: National Trends and Outcomes Associated with Procedural Sleeve Gastrectomy vs Historical Bariatric Surgery Among US Hospitalized Patients 2009-2020.Obesity surgery · 2023
Article
Current opinion on the regulation of small intestinal magnesium absorption.World journal of gastroenterology · 2023
Review
Mechanisms of proton pump inhibitor-induced hypomagnesemia.Acta physiologica (Oxford, England) · 2022
Review
Fibroblast growth factor-23 and parathyroid hormone suppress small intestinal magnesium absorption.Physiological reports · 2022
Article
Mass spectrometric analysis of TRPM6 and TRPM7 from small intestine of omeprazole-induced hypomagnesemic rats.Frontiers in oncology · 2022
Article
Editorial: Ion channels & homeostasis of ions in cancer cell fate.Frontiers in oncology · 2022
Article
Severe hypomagnesemia.Journal of nephrology · 2021
Article
Effect of prolonged omeprazole administration on segmental intestinal MgWorld journal of gastroenterology · 2020
Article
The inhibitory role of purinergic P2Y receptor on MgThe journal of physiological sciences : JPS · 2019
Article
Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium.PloS one · 2018
Article
The Association between the Use of Proton Pump Inhibitors and the Risk of Hypomagnesemia in a National Cohort of Veteran Patients with HIV.Journal of the International Association of Providers of AIDS Care
Article
The Effect of Omeprazole on Urinary Magnesium Excretion in Children with Peptic Diseases.Journal of research in pharmacy practice
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Narongrit ThongonDivision of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Rd., Saensook, Muang, Chonburi, 20131, Thailand. narongritt@buu.ac.th.

Jirawat PenguyDivision of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Rd., Saensook, Muang, Chonburi, 20131, Thailand.

Sasikan KulwongDivision of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Rd., Saensook, Muang, Chonburi, 20131, Thailand.

Kanyanat KhongmueangDivision of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Rd., Saensook, Muang, Chonburi, 20131, Thailand.

Matthana ThongmaDivision of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Rd., Saensook, Muang, Chonburi, 20131, Thailand.

Burapha University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypomagnesemia is the most concerned side effect of proton pump inhibitors (PPIs) in chronic users. However, the mechanism of PPIs-induced systemic Mg

Indexed as

AnimalsAnti-Ulcer AgentsCation Transport ProteinsClaudinsDuodenumIntestinal AbsorptionMagnesiumMagnesium DeficiencyMaleOmeprazoleRatsRats, Sprague-DawleyTRPM Cation ChannelsAnti-Ulcer AgentsCation Transport ProteinsClaudinsCnnm4 protein, ratMagnesiumOmeprazoleTRPM6 protein, ratTRPM Cation ChannelsHypomagnesemiaIntestinal Mg2+absorptionMg2+ homeostasisProton pump inhibitorsUssing chamber

Identifiers

PMID27866273

DOI10.1007/s00424-016-1905-7

OpenAlexW2552071867

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.