Evidence map›Paper›PMID 27866221›Full record

ReviewCellular and molecular life sciences : CMLS2017

Inter-organ regulation of adipose tissue browning.

Simeng Wang, Xiaoyong Yang

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Effect of Vitamin DNutrients · 2019
    Trial
  2. Article
  3. Article
  4. Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  5. βCells · 2021
    Article
  6. Review
  7. Review
  8. Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Article
  9. Article
  10. Inter-tissue communication in cancer cachexia.Nature reviews. Endocrinology · 2018
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Simeng WangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, USA.
Xiaoyong YangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, USA. xiaoyong.yang@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Translational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2001 to 2020
$25.6M
O-GlcNAc Modification in Metabolic HomeostasisR01DK089098 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2010 to 2021
$3.0M
O-GlcNAc Signaling in Central Control of Energy BalanceR01DK102648 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2016 to 2019
$1.8M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016359NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK089098NIDDK NIH HHS R01 DK102648
6 · The paper itself

Abstract

Adaptive thermogenesis is an important component of energy expenditure. Brown adipocytes are best known for their ability to convert chemical energy into heat. Beige cells are brown-like adipocytes that arise in white adipose tissue in response to certain environmental cues to dissipate heat and improve metabolic homeostasis. A large body of intrinsic factors and external signals are critical for the function of beige adipocytes. In this review, we discuss recent advances in our understanding of neuronal, hormonal, and metabolic regulation of the development and activation of beige adipocytes, with a focus on the regulation of beige adipocytes by other organs, tissues, and cells. Understanding the cellular and molecular mechanisms of inter-organ regulation of adipose tissue browning may provide an avenue for combating obesity and associated diseases.

Indexed as

Adipocytes, BrownAdipose Tissue, BrownAnimalsCentral Nervous SystemEnergy MetabolismGastrointestinal TractHeartHumansMuscle, SkeletalMyocardiumObesitySympathetic Nervous SystemThermogenesisbeige adipocytesbrowninginter-organ crosstalkobesityThermogenesis

Identifiers

PMID27866221
PMCPMC5391269

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.