ArticleGenetics2017
Variability in a Short Tandem Repeat Mediates Complex Epistatic Interactions in Arabidopsis thaliana.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Molecular condensation of the CO/NF-YB/NF-YC/FT complex gates floral transition in Arabidopsis.The EMBO journal · 2025Article
- Genome-wide identification and characterization ofFrontiers in plant science · 2025Article
- Fitness landscapes of human microsatellites.PLoS genetics · 2024Article
- Statistical Genomics Analysis of Simple Sequence Repeats from the Paphiopedilum Malipoense Transcriptome Reveals Control Knob Motifs Modulating Gene Expression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The ALOG domain defines a family of plant-specific transcription factors acting during Arabidopsis flower development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Screening and identification of photoresponse factors in kiwifruit (Actinidia arguta) development.Molecular biology reports · 2024Article
- Expression profiling of ALOG family genes during inflorescence development and abiotic stress responses in rice (Frontiers in genetics · 2024Article
- Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species.Journal of evolutionary biology · 2023Review
- Time of Day Analysis over a Field Grown Developmental Time Course in Rice.Plants (Basel, Switzerland) · 2022Article
- ArabidopsisInternational journal of molecular sciences · 2021Article
- Defining the role of the polyasparagine repeat domain of the S. cerevisiae transcription factor Azf1p.PloS one · 2021Article
- Review
- Molecular characterization of Arabidopsis thaliana LSH1 and LSH2 genes.Genes & genomics · 2020Article
- Article
- Contractions of the C-Terminal Domain ofG3 (Bethesda, Md.) · 2020Article
- On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.The Journal of biological chemistry · 2020Review
- Compensatory Mutations in GI and ZTL May Modulate Temperature Compensation in the Circadian Clock.Plant physiology · 2020Article
- Compound Dynamics and Combinatorial Patterns of Amino Acid Repeats Encode a System of Evolutionary and Developmental Markers.Genome biology and evolution · 2019Article
- Genome-Wide Identification and Characterization of the ALOG Domain Genes in Rice.International journal of genomics · 2019Article
- Massive variation of short tandem repeats with functional consequences across strains ofGenome research · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Short tandem repeats (STRs) are hypervariable genetic elements that occur frequently in coding regions. Their high mutation rate readily generates genetic variation, contributing to adaptive evolution and human diseases. We previously reported that natural ELF3 polyglutamine variants cause reciprocal genetic incompatibilities in two divergent Arabidopsis thaliana backgrounds. Here, we dissect the genetic architecture of this incompatibility, revealing as many as four loci putatively interacting with ELF3 We were able to specifically identify one such ELF3-interacting gene, LSH9 We further used a yeast two-hybrid strategy to identify proteins whose physical interactions with ELF3 were affected by polyglutamine tract length. We found two proteins for which this was the case, ELF4 and AtGLDP1. Using these two approaches, we identify specific genetic interactions and physical mechanisms by which the ELF3 polyglutamine tract may mediate the observed genetic incompatibilities. Our work elucidates how STR variation, which is generally underascertained in population-scale sequencing, can contribute to phenotypic variation. Furthermore, our results support our proposal that highly variable STR loci can contribute to the epistatic component of heritability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.