ArticleG3 (Bethesda, Md.)2017
Correlations of Genotype with Climate Parameters Suggest Caenorhabditis elegans Niche Adaptations.
Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Virulent Parasites Emerge in Hosts With Rising Temperatures.Global change biology · 2026Article
- Global genomic diversity of the selfing nematodebioRxiv : the preprint server for biology · 2026Article
- Wild strains reveal natural variation in C. elegans avoidance behaviors.G3 (Bethesda, Md.) · 2025Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Orsay virus infection increasesBiology letters · 2024Article
- Integrating biogeography and behavioral ecology to rapidly address biodiversity loss.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands.Molecular ecology · 2022Article
- Explaining inter-lab variance in C. elegans N2 lifespan: Making a case for standardized reporting to enhance reproducibility.Experimental gerontology · 2021Article
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- Natural variation in fecundity is correlated with species-wide levels of divergence in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2021Article
- Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
- Wrapping culture plates with Parafilm MBMC research notes · 2019Article
- Deep sampling of HawaiianeLife · 2019Article
- Natural Variation and Genetic Determinants ofGenetics · 2019Article
- Article
- Article
- Article
- A Model for Evolutionary Ecology of Disease: The Case forJournal of nematology · 2017Article
- The genetic basis of natural variation in a phoretic behavior.Nature communications · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Species inhabit a variety of environmental niches, and the adaptation to a particular niche is often controlled by genetic factors, including gene-by-environment interactions. The genes that vary in order to regulate the ability to colonize a niche are often difficult to identify, especially in the context of complex ecological systems and in experimentally uncontrolled natural environments. Quantitative genetic approaches provide an opportunity to investigate correlations between genetic factors and environmental parameters that might define a niche. Previously, we have shown how a collection of 208 whole-genome sequenced wild Caenorhabditis elegans can facilitate association mapping approaches. To correlate climate parameters with the variation found in this collection of wild strains, we used geographic data to exhaustively curate daily weather measurements in short-term (3 month), middle-term (one year), and long-term (three year) durations surrounding the date of strain isolation. These climate parameters were used as quantitative traits in association mapping approaches, where we identified 11 quantitative trait loci (QTL) for three climatic variables: elevation, relative humidity, and average temperature. We then narrowed the genomic interval of interest to identify gene candidates with variants potentially underlying phenotypic differences. Additionally, we performed two-strain competition assays at high and low temperatures to validate a QTL that could underlie adaptation to temperature and found suggestive evidence supporting that hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.