ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2017
Group III/IV locomotor muscle afferents alter motor cortical and corticospinal excitability and promote central fatigue during cycling exercise.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 123 citations in OpenAlex.
- Effect of Exergaming on Quality of Life, Fatigue, and Strength and Endurance Muscle in Cancer Patients: A Randomized Crossover Trial.Games for health journal · 2023Trial
- Capsaicin and Its Effect on Exercise Performance, Fatigue and Inflammation after Exercise.Nutrients · 2022Trial
- Effects of TRPV1 and TRPA1 activators on the cramp threshold frequency: a randomized, double-blind placebo-controlled trial.European journal of applied physiology · 2017Trial
- On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans.The Journal of physiology · 2026Article
- Post-Stroke Motor Fatigability: Defining and Studying the Impairments That Emerge During Prolonged Motor Tasks.Neurorehabilitation and neural repair · 2026Review
- Corticospinal, reticulospinal and motoneuronal contributions to fatigability during a sustained contraction of the elbow flexors.Experimental physiology · 2026Article
- The efficacy and physiological bases of small muscle mass exercise in health and disease.Experimental physiology · 2026Review
- On the role of descending drive and group III/IV muscle afferent feedback in modulating corticomotoneuronal excitability during knee-extensor exercise.The Journal of physiology · 2026Article
- Non-local Muscle Fatigue in Young and Middle-Aged Women following Fast-Paced Walking.International journal of exercise science · 2026Article
- Neuromuscular Fatigue Profile of Prepubertal and Adult Female Handball Players.Sports (Basel, Switzerland) · 2025Article
- Multimodal neuroimaging of fatigability development.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Gating of Neuroplasticity: Effects and Mechanisms of Acute Aerobic Exercise as a Brain Stimulation for the Sensorimotor Cortex.Advances in neurobiology · 2025Review
- Control of hyperpnoea and pulmonary gas exchange during prolonged exercise: The role of group III/IV muscle afferent feedback.The Journal of physiology · 2024Article
- Reliability of transcranial magnetic stimulation-evoked responses on knee extensor muscles during cycling.Experimental brain research · 2024Article
- Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions.Aging and disease · 2024Review
- Supraspinal, spinal, and motor unit adjustments to fatiguing isometric contractions of the knee extensors at low and high submaximal intensities in males.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Article
- Voluntary activation of the diaphragm after inspiratory pressure threshold loading.Physiological reports · 2023Article
- ASIC3 plays a protective role in delayed-onset muscle soreness (DOMS) through muscle acid sensation during exercise.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Effects of different phenylcapsaicin doses on neuromuscular activity and mechanical performance in trained male subjects: a randomized, triple-blinded, crossover, placebo-controlled trial.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the influence of group III/IV muscle afferents on the development of central fatigue and corticospinal excitability during exercise.
methodsFourteen males performed cycling-exercise both under control-conditions (CTRL) and with lumbar intrathecal fentanyl (FENT) impairing feedback from leg muscle afferents. Transcranial magnetic- and cervicomedullary stimulation was used to monitor cortical versus spinal excitability.
resultsWhile fentanyl-blockade during non-fatiguing cycling had no effect on motor-evoked potentials (MEPs), cervicomedullary-evoked motor potentials (CMEPs) were 13±3% higher (P<0.05), resulting in a decrease in MEP/CMEP (P<0.05). Although the pre- to post-exercise reduction in resting twitch was greater in FENT vs. CTRL (-53±3% vs. -39±3%; P<0.01), the reduction in voluntary muscle activation was smaller (-2±2% vs. -10±2%; P<0.05). Compared to the start of fatiguing exercise, MEPs and CMEPs were unchanged at exhaustion in CTRL. In contrast, MEPs and MEP/CMEP increased 13±3% and 25±6% in FENT (P<0.05).
conclusionDuring non-fatiguing exercise, group III/IV muscle afferents disfacilitate, or inhibit, spinal motoneurons and facilitate motor cortical cells. In contrast, during exhaustive exercise, group III/IV muscle afferents disfacilitate/inhibit the motor cortex and promote central fatigue. SIGNIFICANCE: Group III/IV muscle afferents influence corticospinal excitability and central fatigue during whole-body exercise in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.